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These Big Pharma “treatments” alter the immune system and create chronic pain in the body….
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These harmful Big Pharma chemicals cause chronic pain
The United States is in the midst of an opioid epidemic.
Increasing numbers of people are becoming addicted to opioid painkillers – and dying from using them.
Opioids are very effective at killing pain in the short term.
But a new study shows that opioid drugs alter the immune system and make animals more reactive to pain.
Maybe this is why people need ever-increasing doses for their pain – and that leads to addiction.
These researchers conducted their animal studies at the University of Colorado at Boulder and published their results in the Journal of Anesthesia & Analgesia.
Opioid drugs are among the most commonly prescribed painkillers after surgical procedures.
This study set out to find out if morphine can prolong postsurgical pain in animals.
Morphine is one of the oldest opioids.
“We tested whether postsurgical morphine could prolong postoperative pain in male rats.”
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The scientists gave the animals an experimental surgical procedure known as a laparotomy – an incision into the abdominal cavity of the animal.
They sorted the rats into groups after the surgery:
- One group got a full dose of morphine for 7 days.
- Another group got morphine but they were tapered off it very quickly.
- A third group got no morphine.
“Rats were treated with morphine for 7 days, beginning immediately after laparotomy, while the morphine was tapered in a second group.”
Then the scientists tested the different groups of rats for their response to pain.
Giving the animals morphine increased the amount of time they spent in pain after surgery.
“We found that morphine treatment after laparotomy extended postoperative pain by more than 3 weeks.”
The scientists found that giving animals morphine and then tapering the dose down did not prevent the increased pain that resulted from using morphine.
“Extension of postoperative pain was not related to morphine withdrawal, as it was not prevented by dose tapering.”
The scientists then conducted another experiment whereby they gave the animals morphine for seven days before the surgery.
Giving the animals morphine prior to surgery also extended the length of time they spent in pain.
“We showed that of preoperative morphine, concluding immediately before laparotomy, similarly prolonged postoperative pain.”
These results might seem surprising, given that morphine is very effective at killing pain in the short term.
The scientists investigated the mechanisms behind these results.
The scientists found that increased pain was associated with increased inflammatory markers.
“Prolonged postsurgical pain was associated with increased expression of inflammatory genes.”
The scientists believe that these effects are due to actions on immune cells.
Immune cells have receptors called TLR-4.
Surgical stress activates TLR-4 in the immune cells.
This makes the immune cells more likely to create inflammation and pain.
Opioids, such as morphine, also stimulate the TLR-4 receptors.
Every time these TLR-4 receptors are activated, they become more aggressive.
Surgery followed by opioids leads to repeated activation of the TLR-4 receptors.
The TLR-4 receptors increase inflammatory proteins – leading to pain.
The study indicates that opioids may have an overall detrimental effect on the amount of pain people suffer.
“These studies indicate that morphine can have a deleterious effect on postoperative pain.”
This study shows one of the reasons why opioid drugs are so addictive.
Opioids kill pain – and then increase the sensitivity to pain later.
And then you need more opioids to numb the pain.
These are not the first experiments showing that opioids can increase sensitivity to pain.
“We have previously reported that opioids such as morphine can worsen inflammatory pain and peripheral and central neuropathic pain.”
What’s worse, many of the inflammatory markers that are increased by opioids are associated with chronic disease.
Morphine increased tumor necrosis factor (which means an increased risk of cancer).
Morphine also increased interleukin-1 (and that is associated with rheumatoid arthritis).
Opioids are very good for pain in the short term – but the health risks are massive.
You should see a healthcare professional about dealing with pain management.
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