Dirty mouth, cancer, and how to never need dental work

Dirty mouth, cancer and how to never need dental work

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An approach to oral health that also avoids cancer…

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Dirty mouth, cancer, and how to never need dental work

There is a lot of evidence accumulating about the link between oral health and cancer.

We have a complex microbiome of bacteria and fungus living in our gastrointestinal system.

And all of this begins in the mouth.

For example, this study shows that an overgrowth of bacteria in the mouth can cause periodontal disease AND contribute to cancer.

Researchers at universities in Finland and Sweden conducted this study and published it in the British Journal of Cancer.

Periodontitis (gum disease) is inflammation affecting the areas surrounding the teeth.

And bacteria cause the inflammation of these tissues.

Periodontitis (and the bacteria that cause it) are associated with the onset of cancer.

“Periodontal pathogens have been linked to oral and gastrointestinal carcinogenesis.”

This study investigated the link between these bacteria and the development of cancer.

It seems that one particular strain of bacteria (Treponema denticola) is associated with advanced periodontitis.

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“Treponema denticola bacteria is associated with severe periodontitis, a chronic inflammatory disease leading to tooth loss.”

And this strain of bacteria produces an enzyme that is very similar to a digestive enzyme (it’s called Treponema denticola chymotrypsin-like protease).

The study analyzed tumors for levels of this enzyme.

“We investigated the presence of this bacterial enzyme in tumors to find the mechanisms for its contribution to carcinogenesis.”

And then, after collecting samples of various cancerous tumors, the scientists tested for levels of the bacterial enzyme.

“The presence of Treponema denticola chymotrypsin-like proteinase within orodigestive tumor tissues was examined using immunohistochemistry.”

The study used a technique involving antibody staining to measure the levels of the bacterial enzyme.

“Oral, tonsillar, and esophageal squamous cell carcinomas, alongside gastric, pancreatic, and colon adenocarcinomas, were stained with a Treponema denticola chymotrypsin-like protease specific antibody.”

The researchers found these enzymes (produced by periodontal bacteria) in oral and digestive tumors.

“Treponema denticola chymotrypsin-like proteinase was present in the majority of orodigestive tumor samples.”

The bacterial enzyme affected peptides involved in controlling the rate of cell division and proliferation.

As we know, cancer happens when cell division and proliferation get completely out of control.

The study found evidence that periodontitis-causing bacteria affect the regulation of tumor cells.

And so those bacteria may be a contributing factor to some cancers.

“Because of its presence within tumors and regulatory activity on proteins critical for the regulation of  the tumor microenvironment and inflammation, the bacterial enzyme may contribute to cancer.”

Another recent analysis shows a correlation between periodontal disease and cancer.

Scientists at Tufts University School of Medicine, Johns Hopkins Bloomberg School of Public Health, and Kimmel Cancer Center performed this analysis of population data.

It was published in the Journal of the National Cancer Institute.

The study looked at information from thousands of people and analyzed the relationship between periodontal disease and cancer.

“Included were over 7,000 participants in a study cohort who reported being toothless or underwent the dental examination.”

This analysis found a strong correlation between cancer and periodontal disease among this large sample of people.

“An increased risk of total cancer was observed for severe periodontitis compared with no/mild periodontitis.”

The study found a particular association between periodontal disease and an increased risk of lung cancer and colorectal cancer.

“Strong associations were observed for lung cancer and elevated risks were noted for colorectal cancer for severe periodontitis.”

These two studies add to a growing and already large base of evidence showing the relationship between oral health and cancer.

“This study provides additional evidence that cancer risk, especially for lung and colorectal cancer, is elevated in individuals with periodontitis.”

Look after your oral health.

You should consult a professional about the diagnosis and treatment of cancer.

—–Important Message—-

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.
Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation https://www.nature.com/articles/bjc2017409Periodontal Disease Assessed Using Clinical Dental Measurements and Cancer Risk in the ARIC Study https://academic.oup.com/jnci/advance-article/doi/10.1093/jnci/djx278/4804361

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