When you get an erection, certain muscles must relax.
These are the so-called “smooth muscles” that line the arteries and erection chambers.
And these smooth muscle cells function is harmed by the very thing people are using to treat it.
For years, people have thought that nitric oxide causes this relaxation.
But that’s just Big Pharma lying to us.
In the early 1990s, Big Pharma accidentally discovered Viagra.
And Viagra works by maintaining high nitric oxide levels in the body.
They never asked is nitric oxide good for you.
But nitric oxide is very bad for us.
In the human body, nitric oxide is responsible for leaky arteries.
It can age your arteries and make them non-functional — the way diabetic arteries and kidneys are.
They discovered that chronic build up of nitric oxide leads to some dangerous consequences.
And this is when you take PDE5 inhibitors at levels that are similar to what you get with drugs Viagra, Cialis, or Levitra.
They found that this chronic nitric oxide build up:
may be involved in the progressive cellular loss occurring in vascular and glomerular diabetic sclerosis.
This finding is a great reason not to take all the so-called “men’s supplements” that have L-arginine in them.
L-arginine increases nitric oxide levels in the body, which is exactly what you do not want to do.
But Big Pharma has people convinced that nitric oxide is a good thing, so they take it.
And all the brainwashing from the drug companies has resulted in a ton of research about the role of PDE5 inhibitors.
Despite the fact that about 50% of men who take them find that they don’t work.
However, luckily, there are other ways of getting an erection rather than nitric oxide.
In fact, the so-called “nitric oxide erection” is just one of many types of erections.
And most of these other erections are quite a lot better and healthier.
This study gives me hope that we may move the conversation away from harmful nitric oxide.
Maybe eventually we’ll start talking about good quality, solid, rigid erections that last a long time thanks to the rho-kinase pathway.
Rho kinase potentiates smooth-muscle relaxation in an nitric oxide-independent manner.
The mechanisms and effects that this pathway could prove to be a new therapeutic target for the treatment of ED.
Let’s look at a real test of this rho-kinase pathway.
These researchers performed their experiments on rats, not humans.
But there is every reason to believe that the same mechanism works in people.
Rho-kinase antagonism stimulates rat penile erection independently of nitric oxide, introduces a potential alternate avenue for the treatment of erectile dysfunction.
This finding gives new hope to men who do not want to load their bodies with dangerous nitric oxide.
There are already a number of herbs that can work this way.
I’ll share more in a future newsletter.
Understanding and targeting the Rho kinase pathway in erectile dysfunction
Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway