Using progesterone this way can heal an injury faster

Young fitness man holding his sports leg injury.

It lessens recovery time after working out, and speeds up cell and tissue regeneration for faster healing

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—-Important Message—-

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Using progesterone this way can heal an injury faster

The body’s ability to heal itself is dependent on its capacity to generate energy.

Energy generation is dependent on numerous factors, including hormones.

I believe optimizing your hormones can keep you biologically younger and healthier.

Exciting new research has shown that hormone therapy can even help with limb regeneration in frogs.

We don’t know yet whether hormones could help humans to regrow arms and legs — but they sure can help you recover from stress and injury more efficiently.

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These animal experiments were carried out at Tufts University. The findings were published in Cell Reports.

Animals exhibit different responses after injury.

After amputation, some frogs develop spikes where their limbs were — spikes which look like the beginnings of new limbs.

“The severed hindlimbs of adult Xenopus laevis frogs normally regenerate cartilaginous spikes after amputation.”

Other animals, particularly some other amphibians, are known to be able to regenerate limbs almost entirely — given the right environment.

For example, some salamanders can completely regenerate their tail after it has been cut off.

So why do frogs grow little stumps, while salamanders can grow full tails?

In these experiments, the researchers tested out methods designed to accelerate recovery and regeneration after injury.

Injury causes an increase of stress compounds at the site of injury and in the rest of the body.

One of these stress compounds is estrogen.

Estrogen can inhibit recovery. However, another hormone acts against the effects of estrogen, namely progesterone.

Prior experiments have shown that progesterone can accelerate recovery and regeneration of various tissues.

“Progesterone shows promise for peripheral nerve regeneration and bridging in severed rabbit facial nerves, canine sciatic nerves , and non-neural tissue remodeling by modulating the inflammatory response to drive wound healing, angiogenesis, and bone remodeling.”

The researchers wondered whether progesterone application could cause these frogs to grow larger spikes after losing a limb.

“We asked whether a treatment with a progesterone containing silk device immediately after amputation would improve regenerative potential after hind limb amputation.”

The researchers amputated the rear legs of adult frogs. 

After amputation, some frogs were treated with silk bandages infused with progesterone.

The hormonal treatment was effective at increasing regeneration in the severed limbs.

“A silk protein-based hydrogel that delivered progesterone to the wound site immediately after hindlimb amputation for only 24 hr induced the regeneration of paddle-like structures in adult frogs.”

The animals were only given progesterone for 24 hours — but accelerated regeneration continued long after that period.

Biochemical and structural analysis showed remarkable improvements in limb regeneration from the treatment.

“Molecular markers, morphometric analysis and x-ray imaging were used to characterize the differences.”

In these early experiments, the frogs did not grow complete hind limbs after the treatment — but…

The regenerated tissues were much larger and more similar to the original limb when treated with progesterone.

What’s more, the animals were able to use the regenerated spike in a functional manner.

“These patterned structures or ‘paddles’ could be recognized and used by the animals in swimming and/or active behaviors similar to the original limb.”

Given the right environment, animals and humans could recover and regenerate at a level previously only seen in sci-fi movies.

“Our experiments establish pro-regenerative activities of progesterone-containing bioreactors, and provide proof of principle of brief use of integrated device-based delivery of small-molecule drugs as a viable strategy to induce and maintain a long-term regenerative response.”

You should always consult a healthcare practitioner about treating and diagnosing health-related problems.

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.


 

Brief Local Application of Progesterone via a Wearable Bioreactor Induces Long-Term Regenerative Response in Adult Xenopus Hindlimb.

https://www.ncbi.nlm.nih.gov/pubmed/?term=Brief+Local+Application+of+Progesterone+via+a+Wearable+Bioreactor+Induces+Long-Term+Regenerative+Response+in+Adult+Xenopus+Hindlimb