Does fish oil really lead to prostate cancer?

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Does fish oil really lead to prostate cancer?

Matt Cook here, and we’ve been told that the male hormones testosterone and DHT are the cause of prostate cancer.

This is entirely untrue – in fact, the research shows that these hormones are protective against the disease.

In reality, many substances which we have been led to believe are health-giving are actually the cause of diseases like prostate cancer.

Numerous studies have implicated fats found in fish oils as causing an increased risk of prostate cancer.

Potential mechanisms include immune suppression, increased leakiness leading to bacterial inflammation of the prostate, and decreased energetic metabolism.

All of which increase the risk of cancers and other chronic diseases.

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The human research was carried out at The Ohio State University College of Medicine. The paper was published in the journal of The National Cancer Institute.

The researchers were investigating prior studies which had highlighted omega-3 fatty acids as a risk factor for prostate cancer.

Omega-3 fatty acids are unstable fats which are found in high amounts in fatty fish and fish oil supplements.

Fish oils are some of the most popular supplements in the world.

“Recent large prospective studies have found increased risk of prostate cancer among men with high blood concentrations of long-chain omega-3 polyunsaturated fatty acids.”

These fats are EPA, DHA, and DPA – found largely in fish and dish oil.

The researchers used data from an already existing prostate cancer prevention study which had information on fatty acid levels in the blood of men.

“This case-cohort study examines associations between plasma phospholipid fatty acids and prostate cancer risk among participants in the Selenium and Vitamin E Cancer Prevention Trial.”

The research included data and over a 1000 men who had developed cancer during the trial.

“Case subjects were 834 men diagnosed with prostate cancer, of which 156 had high-grade cancer”.

The researchers looked at the risk of developing prostate cancer according to the levels of these fats in blood plasma.

They also looked at the risk of different grades of prostate cancer in the same context.

“Proportional hazards models estimated hazard ratios for associations between fatty acids and prostate cancer risk overall and by grade.”

Men with high levels of fish oil fats in their blood were over 40% more likely to have a diagnosis of prostate cancer.

A diagnosis of prostate cancer generally isn’t as bad as it stands – most low-grade prostate cancers are not a threat to your life.

But the rarer high-grade prostate cancers can be something to worry about. And these types of cancers were even more likely in men with higher levels of omega-3 polyunsaturated fatty acids in the blood.

Men with the high levels of fish oils in their blood were more than 70% more likely to receive a diagnosis of high-grade prostate cancer.

“Compared with men in the lowest quartiles of omega-3 fatty acids, men in the highest quartile had increased risks for high-grade (HR = 1.7), and total prostate cancer (HR = 1.4).”

The researchers found that the risks were similar when they looked individually at the 3 different fatty acids (EPA, DHA, and DPA).

“Associations were similar for individual long-chain ω-3 fatty acids.”

The results are in line with some other studies that have looked into the topic.

“This study confirms previous reports of increased prostate cancer risk among men with high blood concentrations of long-chain omega-3 polyunsaturated fatty acids.”

Men who have higher levels of fish oil fats in their blood were more likely to receive a diagnosis of prostate cancer and far more likely to receive a diagnosis of high-grade prostate cancer.

There are numerous mechanisms which could explain the increased risk of cancer too.

Immune suppression, increased leakiness, decreased energy production, and elevated estrogen to name a few.

These types of fats are associated with other types of cancer as well.

“The consistency of these findings suggests that these fatty acids are involved in prostate tumorigenesis. Recommendations to increase long-chain omega-3 polyunsaturated fatty acids intake should consider its potential risks.”

You should always consult your healthcare practitioner for guidance on medical diagnosis and treatment.

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.
Plasma phospholipid fatty acids and prostate cancer risk in the SELECT trial