Breakthrough British medical discovery reveals a new way to breathe that could add decades to your life…
This 90-Second Breathing Exercise Increases Oxygen to the Penis
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How does it work?
Your erections depend upon two things:
- Blood supply
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This Drink Increases Oxygen and Extends Life by Decades
Today this newsletter is going to tackle breathing…
And how breathing can actually be the most effective treatment for over 200 chronic diseases.
Especially erectile dysfunction.
We will start with asthma, but this newsletter is NOT about asthma. Just bear with me here…
So… There are a handful of classic treatments for asthma.
Perhaps most notable are the adrenaline-like inhalants such as ephedrine and Albuterol™.
These work on the beta-adrenaline receptor, are fast-acting, and often reserved for emergencies.
A plant alkaloid called atropine is perhaps the most historically infamous.
Atropine works on the muscarinic receptor type two, the same receptor that toxic proteins derived from eosinophils (specialized immune cells) strongly bind and inhibit.
But, just like the powerful beta-adrenergic treatments, atropine only really works well during attacks.
These treatments are quickly metabolized, the effects wear off quickly, and they basically need to be inhaled to work – or to work safely.
So we certainly need improved treatments that increase airflow – with a longer half-life than the ones we have now…
And especially ones that can be consumed safely for decades – or even for a few months.
Of the slow-acting and slow-metabolizing twice-daily types, the glucocorticoids are undoubtedly the most prescribed.
These are powerful, patented, and dangerous…
Yet they will actually reduce eosinophils in the lungs, in most cases.
However, in addition to being the most dangerous asthma treatments, they don’t even always work.
In many instances of asthma fatalities, the patients are found to still have eosinophils in their lungs – this is despite them having taken glucocorticoids.
And the term “steroid-resistant asthma” has been in common usage since the mid-1990s.
Due to the dangerous immune effects and metabolic consequences that result from glucocorticoids, these should probably be the last resort…if considered at all.
But there’s another class of slow-acting asthma treatments that were in common use before dexamethasone and prednisolone were ever synthesized: the methylxanthines.
Theophylline is one of a small handful of classic asthma drugs used for over a century – it’s still in use to this day, though not hugely.
“The notion of caffeine-induced bronchodilation is also evident in the common practice of advising patients to avoid caffeine-containing products prior to pulmonary function tests for clinical and research purposes.”
These treatments work primarily on the cyclic phosphodiesterase receptor and increase cyclic ATP…
And that’s great, although they do also bind the adenosine receptor.
Looking at adenine – part of cyclic ATP – it’s easy to see why:
But caffeine is also a methylxanthine.
Besides being slow to metabolize, when it does so it doesn’t lose potency.
It partially becomes active theophylline and theobromine.
Evidence shows that caffeine itself opens up the airways…
Caffeine has been shown to be roughly half as effective as theophylline itself.
And theobromine has been shown to be as effective as theophylline – another metabolite of caffeine.
Most treatments become completely inactive after they’re metabolized, but caffeine only does that slightly.
While its primary metabolite paraxanthine is essentially inactive, the two others – theophylline and theobromine – account for about 30%.
And these two methylxanthines also have longer half-lives.
As caffeine wears off, theobromine and theophylline levels increase. And they don’t peak until eight hours later.
This makes twice-daily coffee-drinking a historically safe and approachable method to open airways.
Why exactly coffee is thought to be “unhealthy” is beyond me…
Maybe it has something to do with how it speeds up the metabolism.
Coffee burns through B vitamins at a faster rate, and these could be nearly depleted in people with bad diets.
But we shouldn’t be lacking in these vitamins. They are abundant in fresh food.
Much of the stimulant effects of coffee are probably due to its caffeoyl quinine content, an anti-opiate molecule that is formed upon roasting.
But caffeine pills would be entirely free of this coffee drug, so don’t consider them to be the same as actual coffee.
Historically, theophylline was compounded in pills with ephedrine and caffeine, and it is no accident that caffeine is in modern ephedra pills.
And coffee actually works, as is shown by the following study:
In a double-blind placebo-controlled study spanning days, researchers gave adult humans either decaffeinated coffee, caffeinated coffee, theophylline, or none of the above.
They measured airflow, lung volume, and lung resistance using whole-body spirometry.
The results indicate that caffeine actually works to improve these three parameters – and even approaches the efficacy of theophylline in every respect:
From knowing the blood concentrations and doses used, the study author calculated that caffeine was 40% as effective as the classic asthma treatment, theophylline.
“Therefore, caffeine is approximately 40% as potent as theophylline on a milligram-for-milligram basis in producing equivalent bronchodilation.”
And caffeine will actually become theophylline itself (besides being effective in its own right), and it also becomes theobromine.
Theobromine is also a methylxanthine…
And this also works:
This study was very similar to the other one, but this time they compared theophylline to theobromine.
Before this, they thought that theobromine was less effective in this regard based on receptor binding affinities and lower absorption…
And those things are true, but they found it to be equally effective.
At twice the oral dose – to correct for lower absorption – theobromine has the same blood concentration as theophylline.
And when their effects are analyzed at equal blood concentrations (more fairly), they are indistinguishable:
They are incredibly close.
Both the methylxanthines were highly correlated with lung function, and both to the same extent:
Pearson coefficients for theobromine and theophylline below:
- FEV₁: r=0.81 and r=0.73
- V₂₅: r=0.63 and r=0.86
- FEV₁/FVC: r=0.53 and r=0.67
- FEFdynamic: r=0.88 and r=0.85
Caffeine is the most water-soluble of the three methylxanthines and hence the most readily absorbed.
So caffeine can be thought to serve as a prodrug for the other two, but one that is also a drug itself.
As the caffeine levels fall over a few hours, the levels of both theobromine and theophylline increase.
And there’s even epidemiological evidence from Italy showing that coffee is correlated with reduced asthma:
This was a very, very large study group.
They nested questions about coffee consumption into a massive survey, conducted door-to-door by civil servants.
A total of 72,284 individuals were interviewed forming the basis for the best epidemiological data on coffee and asthma.
And they found significant dose-dependent effects:
“Compared with subjects who did not drink coffee, the age and sex-adjusted relative risks were 0.95 for one cup, 0.77 for two, and 0.72 for three or more cups per day.”
With so many people, this is a huge finding…
And with a 93.4% participation rate, it can’t be argued to have any selection bias.
This study was conducted in Italy, where one cup of coffee is like a shot.
Arguably, “three cups” in this case actually represents about one American cup (16 oz), or about 259–564 mg of caffeine.
Caffeine obviously does work to increase lung volume, air flow, and resistance – and is safe enough to consume for decades.
But with the long half-life of its potent metabolites, you can expect it to work for hours at a time…
Even for days because theophylline’s long half-life allows it to build up over time.
“Our results indicate that caffeine causes acute bronchodilation, with a significant dose-response relationship between serum caffeine concentration and pulmonary function.”
This Liver Cleanse Makes Erections Better – Here’s How
The liver is our body’s first defense against toxins. It has to siphon out all the bad stuff from everything we eat and drink.
So it’s no wonder that as we age, our liver starts getting bogged down by all these toxins.
And it stops working as well.
And when the liver is clogged up and not working as well, men’s testosterone levels plummet.
That’s why men who want great erections and a tremendous sex life always start by cleansing their liver…
Because when men have a clean liver, testosterone naturally starts rising again…
And that makes erections much better. Stiffies become stiffer and longer-lasting, and men gain a lot more sexual confidence.
So I’ve created a special liver cleanse just for men who want to roll back the clock on their aging liver and clean it up for much better erections.
- Welsh, E. "Caffeine for asthma." The Cochrane Library (2010). http://www.academia.edu/download/45314581/Caffeine_for_asthma20160503-29931-rqmqlc.pdf
- Gong, H. "Bronchodilator effects of caffeine in coffee: a dose-response study of asthmatic subjects." Chest (1986) https://pdfs.semanticscholar.org/cba4/ff971de4b380cf2fc4bbb4b7b09073ac2f05.pdf
- Simons, F. "The bronchodilator effect and pharmacokinetics of theobromine in young patients with asthma." Journal of allergy and clinical immunology (1985) http://www.jacionline.org/article/0091-6749(85)90674-8/pdf
- Lelo, A. "Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man." British journal of clinical pharmacology (1986) https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2125.1986.tb05246.x
- Weinberger, M. "Theophylline in asthma." New England Journal of Medicine (1996) https://www.researchgate.net/profile/Miles_Weinberger/publication/14586982_Theophylline_in_Asthma/links/542964e10cf26120b7b6c758.pdf
- Pagano, R. "Coffee drinking and prevalence of bronchial asthma." Chest (1988) https://www.researchgate.net/profile/Eva_Negri/publication/19760754_Coffee_drinking_and_prevalence_of_bronchial_asthma/links/09e415111525eea9ce000000/Coffee-drinking-and-prevalence-of-bronchial-asthma.pdf