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Finally good bowel movements every day with this
Only about 54% of people excrete detectable methane levels in their breath.
In these people, it has been correlated with both constipation and body weight in a dose-dependent manner.
Methane has also been shown to prolong transit time when infused directly into the intestines.
This slow transit time results in constipation…
And, even worse, endotoxins that travel to the liver and the brain – wreaking metabolic havoc.
So it is increasingly clear that methane is among the fundamental causes of constipation and high endotoxin load.
Of course, that’s along with opiates and epinephrine.
And studies show that that just one microbial species, Methanobrevibacter smithii, is accountable for essentially all methane production in humans.
In fact, M. smithii is not actually a bacteria.
It’s a more primitive and radically distinct form of life: an archaeon.
As such, M. smithii is resistant to most antibiotics.
“Archaea are characterized by their broad-spectrum resistance to antimicrobial agents. In particular, their cell wall lacks peptidoglycan, making them resistant to antimicrobial agents interfering with peptidoglycan biosynthesis.”
Yet M. smithii is not indestructible. It does have an Achilles heel – two of them in fact.
First of all: This species is highly sensitive to statins, of all things, on account of its unique cell wall comprised of isoprenoid lipids.
And secondly: M. smithii is highly vulnerable to oxygen gas, and even to just plain air.
So methane-producing archaea can be diminished by certain mushrooms that naturally contain lovastatin.
These include Cordyceps sinensis (caterpillar fungus) and Pleurotus ostreatus (pearl oyster mushroom).
And methane-producing archaea can also be reduced by oxygen-releasing agents.
Compounds such as sodium percarbonate, carbamide peroxide, and magnesium peroxide are dry-solid compounds that slowly release oxygen over time.
Not surprisingly, these compounds are often sold in “colon cleanse” formulations.
And they’re also in a few other over-the-counter consumer products.
For any chemistry geeks reading this:
H2 2·MgO2 + 4·H2O → 2·Mg(OH)2 + O2 + 2·H2O
Now, our intestines aren’t plastered with as much debris as marketers (e.g. Oxy-Powder) like to claim…
But taking magnesium peroxide really can have many benefits.
Studies show that oxygenating the colon decreases the number of anaerobic bacteria, archaea, and yeast (the bad guys).
At the same time, it increases those of aerobic species (the good guys).
For this reason, taking an oxygen-releasing compound such as magnesium peroxide should lower levels of:
(1) The M. smithii archaeon
(2) The methane it produces
(3) And (therefore) constipation
“M. bryantii, M. voltae, and M. smithii cells were assayed for methanogenesis and all three were inhibited by…oxygen.”
Surprisingly (or maybe not), exercise should also help.
That’s because exercise helps oxygen from the blood diffuse into the intestines where it modulates intestinal flora.
Now, it’s normal and even unavoidable to have small amounts of M. smithii in the colon…
But M. smithii can also inhabit the small intestine in certain instances.
This could be what differentiates people who excrete methane in their breath from people who do not…
And M. smithii in the small intestine may well be the underlying cause of constipation for many people.
Though perhaps not as specific as statins against archaea, oxygen and oxygen-releasing compounds only target anaerobic species (the bad guys).
All human cells are left alone, along with aerobic bacteria (the good guys).
So oxygen can be considered semi-specific against M. smithii because it’s an anaerobe.
It’s also somewhat potent, as seen below:
This study used five species of microorganisms from four genera, all of which produce and emit methane gas.
They incubated these methanogens in flasks containing a mixture of 80% hydrogen and 20% carbon dioxide.
And those two things, besides being free of oxygen, are also their fuel.
Methanogens ultimately derive their energy from hydrogen reacting with carbon dioxide.
And they form methane and water in the process.
Methanogens have a folate-like coenzyme to carry the carbon atom and a flavin-like coenzyme for adding the hydrogens.
The researchers tested for methane from the headspace of the flasks. And they found a significant amount.
But, upon addition of air, all the microorganisms started to die.
And (see graphic below) this was not because of restricting hydrogen (left), as replacing that with nitrogen had little effect on their survival (right):
So, despite archaea being resistant to most antibiotics, they ARE vulnerable to oxygen…
Even just the oxygen that’s in plain old air.
And, besides being SAFER than pharmaceutical antibiotics, oxygen-releasing compounds are also MORE EFFECTIVE against M. smithii.
In fact, drugs such as penicillin and tetracycline allow methanogens to proliferate by killing off their competition.
And that’s ironic – scientists used to think archaea WERE bacteria.
“This strain was reported to be resistant to polymyxin E and several other antimicrobials, including penicillin, ampicillin, streptomycin, tetracycline, bacitracin, neomycin, and sulphafurazole…”
Oxygen-releasing compounds are safe to take, and there is no harm to be expected from taking magnesium peroxide.
Any oxygen released that is not used by the body to destroy M. smithii can be absorbed into the bloodstream.
And then we either use it for energy or exhale it if we don’t need it.
Oxygen also allows beneficial aerobic bacteria to flourish…
And that’s competition – another way oxygen helps diminish methanogen populations.
This effect was proven just last year in a patent application.
In this application, they gave magnesium peroxide and sodium percarbonate to humans:
It’s true that most patent applications have an inherent financial bias and aren’t peer-reviewed.
But I see no reason to doubt their veracity if the results conform to logical expectations.
And what happens in this study is exactly what you would expect:
Oxygen-releasing compounds effectively reduce anaerobic (bad) bacteria while promoting the growth of aerobic (good) species.
A more detailed analysis of human intestinal bacteria showed an increase in Thallasospira, an aerobic order consisting mainly of the family Acetobacteraceae.
Most species of this category can use hydrogen gas, thereby depriving methanogens of their prime energy source and substrate for methane production.
The beneficial bacteria in apple cider vinegar (Acetobacter aceti) belong to this category.
This expected increase of oxygen-tolerant bacteria occurred at the expense of Parasutterella, an anaerobic (bad) genus.
“The inventor has discovered that administering an effective amount to the small intestine and/or large intestine of a subject of at least one agent that increases oxygen tension and/or redox potential and/or pH in the colon of the subject has a beneficial effect on the gut microbiome of the subject.”
Although they didn’t measure methanogens specifically, you could infer a reduction in those as well.
AND the supplementation of oxygen-releasing compounds lowered body weight by a few percentage points.
So, in addition to statins and tannins, oxygen-releasing compounds can be considered methane-reducing agents.
So here’s another summary of the microbial shifts that magnesium peroxide should induce:
(1) Reduction in methanogens
(2) Reduction in methane production
(3) Elimination of constipation
(4) And even a slimming effect
To tie this all up, breath methane was already correlated with increased body weight by previous studies, an observation generally explained through constipation.
“Magnesium peroxide and calcium peroxide were reported to be orders of magnitude less water soluble than sodium percarbonate (Weast 1998), which allows them to release oxygen over prolonged periods… A batch study indicated that magnesium peroxide released oxygen for up to 300 days, while [arterial oxygen content] and [hydrogen peroxide] were exhausted after 100 and 10 days respectively.”
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- Khelaifia, S. "Susceptibility of archaea to antimicrobial agents: applications to clinical microbiology." Clinical Microbiology and Infection (2012) https://core.ac.uk/download/pdf/82572472.pdf
- Kiener, Andreas. "Oxygen sensitivity of methanogenic bacteria." Systematic and Applied Microbiology (1983) https://www.sciencedirect.com/science/article/pii/S0723202083800174
- Celiker, Hasan. "Methods and compositions to modulate the gut microbiota and to manage weight." U.S. Patent Application No. 15/575,942 (2018) https://patentimages.storage.googleapis.com/42/70/e1/ea8a898bdbb16b/US20180147167A1.pdf
- Oxygen release compound as a chemical treatment for nutrient rich estuary sediments and water. https://www.ncbi.nlm.nih.gov/pubmed/19412853/
- Oxygen Release Compound (ORC®) https://regenesis.com/en/oxygen-release-compound-orc/