Why I’m against nitric oxide — and what I use instead

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Here’s proof of what too much nitric oxide does to men’s bodies…

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Why I’m against nitric oxide — and what I use instead

Nitric oxide is a gas which can be produced in the body.

This gas has many effects in the body. One of the most interesting effects is its ability to relax blood vessels (vasodilation).

Vasodilation can lead to lower blood pressure, better boners, and increased “pump” and vascularity in the gym.

Because of this, there are many popular substances and supplements which work by increasing nitric oxide.

But nitric oxide is a harmful gas — healthy vasodilation occurs through other methods, primarily CO2.

One particular study looked at the effect of nitric oxide on rats exposed to a toxin produced by gut bacteria.

Nitric oxide increased mortality (death) in the animals, highlighting its danger.

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These animal experiments were carried out at the Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan, R.O.C.

The results were published in Life Sciences.

Some bacteria which live in the gut produce a toxin called endotoxin, or lipopolysaccharide (LPS).

This toxin can get into the bloodstream where it causes inflammation.

Endotoxin is a major cause of chronic disease. It is also a major cause of death from sepsis.

Everyone is exposed to some level of endotoxin — the more you’re exposed to, the worse your health.

And in recent years there has been an increasing use of supplements and treatments which increase nitric oxide.

This combination could be deadly.

In this series of experiments, researchers looked at the effect of nitric oxide and endotoxin in rats.

“We investigated whether nitric oxide contributed to a higher mortality induced by LPS in spontaneously hypertensive rats, NO synthase inhibitors were used to examine the mortality in SHR and normotensive rats.”

In the experiments, the rats were anesthetized. Then they were given varying doses of endotoxin.

“We evaluated the mortality from LPS in a series of doses (5, 10, or 20 mg/kg, i.v.) in the anesthetized rat.”

Some of the rats were given compounds which block the production of nitric oxide. (L-NAME and aminoguanidine/AG)

Endotoxin kills rats.

Higher doses of endotoxin killed more rats faster. Those with a tendency to high blood pressure fared worse.

“Injection of endotoxin caused a dose-dependent mortality in both strains, having a more marked effect in spontaneously hypertensive rats.”

Now, nitric oxide is widely recommended as a treatment for high blood pressure…

But the animals with higher blood pressure were more susceptible to endotoxin poisoning.

The researchers then looked at the effect of nitric oxide lowering compounds on death rate in the rats.

These compounds had little effect in the healthy rats.

“The administration of L-NAME and AG, 3 h after LPS had no significant effects on the survival time of normal rats.”

But, lowering nitric oxide significantly increased survival in the rats with high blood pressure.

“The administration of the NO-lowering compounds significantly prolonged survival time of spontaneously hypertensive rats.”

When nitric oxide was lowered, the hypertensive rats lived as long as normal rats after endotoxin exposure.

Increasing nitric oxide can be dangerous when combined with endotoxin exposure — which is ubiquitous.

“These results suggest that a higher level of NO evoked by LPS is associated with a higher mortality in hypertensive rats and we propose that the elevated NO synthesis may play an important role in the compensatory mechanisms activated to combat the hypertensive state.”

Increasing nitric oxide can have seeming immediate benefits — but I believe the risks are too great and there are safer methods to achieve desired results.

You should consult a healthcare practitioner about treating and diagnosing health-related problems.

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.