Most men don’t realize this problem is so easily solved by lowering estrogen
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Watch out for this male condition caused by high estrogen
Maybe you know someone who has seizures. If so, read this carefully and maybe forward it to them.
There can be several causes of seizures, including stress, trauma, fever, sleep deprivation, pre-eclampsia, CNS infections, brain tumors, dementia, etc.
It is most famously associated with epilepsy, and is characterized by an excitatory state of excessive brain neuronal activity.
Seizures do not always include the convulsions which are associated with them, but it remains a debilitating condition, and can be a source of recurring problems for many people.
Seizures are probably associated with the excitatory state promoted by estrogen.
Estrogen levels are modulated by the activity of the enzyme aromatase.
In men, testosterone, which is otherwise protective, can get transformed into estrogen by the aromatase enzyme.
This process occurs under the influence of stress.
“(…) the estradiol metabolite of testosterone increases brain excitability, while the reduced metabolite of testosterone, 3alpha-androstanediol, decreases brain excitability, likely through an action at the gamma-amino butyric acid A receptor. Therefore, the metabolites of testosterone produce opposite effects on brain excitability in seizure models. Aromatase is the enzyme for the conversion of testosterone to 17beta-estradiol. Aromatase inhibitors could decrease brain excitability by decreasing local estradiol levels and therefore, could be beneficial for the treatment of epilepsy.” – Harden & MacLusky (2005)
In men with epilepsy, the use of aromatase inhibitors predictably increased testosterone levels (by preventing it from being turned into estrogen) and reduced the occurrence of seizures.
We report herein a 61-year-old man with temporal lobe epilepsy and sexual dysfunction due to low testosterone levels. Use of an aromatase inhibitor, letrozole, normalized his testosterone level and improved his sexual functioning. Letrozole, in addition to standard antiseizure medication, was also associated with improved seizure control. This was sustained and, further, was associated with seizure exacerbation after withdrawing letrozole, and subsequent seizure improvement after restarting it. – Harden & MacLusky (2004)
A perhaps safer alternative to the use of aromatase inhibitors (AIs) is progesterone.
In a way, progesterone is the polar opposite of estrogen in the body.
It is the body’s endogenous aromatase inhibitor while being much safer than any synthetic AI.
Progesterone has an inhibitory, quieting effect on the brain and nervous system.
Aside from its effect in opposing estrogen and aromatase, it is also a GABA agonist.
GABA is the main inhibitory neurotransmitter which has profound calming effects.
A 2018 paper by Wu & Burnham reviewed the effects of progesterone for seizures:
‘’The anti-seizure effects of progesterone family compounds have long been known. Progesterone and its reduced metabolites all have demonstrated seizure-suppression effects in animal models – except in models of absence seizures – with the common side effects of sedation and ataxia.’’ – Wu & Burnham (2018)
Furthermore, progesterone’s protective effect go far beyond simply preventing seizures, it also seems to address neuroinflammation:
“In addition to their acute anti-seizure actions, compounds in the progesterone family might also alleviate difficult-to-treat seizures by modulating neuroinflammation.” – Wu & Burnham (2018)
Another interesting point is that men with epilepsy have low testosterone levels, and progesterone is itself a potential precursor of testosterone.
All in all, progesterone seems like the ideal solution for men (or anyone really) experiencing seizure events. It was used for this decades ago, very successfully.
It also has a myriad of other benefits while being safer than Big Pharma’s aromatase inhibitors.
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Having high testosterone will make your muscles stronger, boost your drive and stamina, and give you an extra “oomph” when working out or getting busy in bed.
And scientists found that men with higher natural testosterone live longer than men with low testosterone!
So raising testosterone is the best thing you can do as a man.
Wu YV, Burnham WM. Progesterone, 5a-dihydroprogesterone and allopregnanolone's effects on seizures: A review of animal and clinical studies. Seizure. 2018 Dec;63:26-36. doi: 10.1016/j.seizure.2018.10.012. Epub 2018 Oct 28. PMID: 30391663.
Harden C, MacLusky NJ. Aromatase inhibition, testosterone, and seizures. Epilepsy Behav. 2004 Apr;5(2):260-3. doi: 10.1016/j.yebeh.2003.12.001. PMID: 15123030.
Danny Roddy, Georgi Dinkov. Generative Energy Podcast #17 - Progesterone/DHEA Study Results | Field Biology | NAFLD | Vitamin E with Georgi Dinkov. Feb. 21 2020. (generativeenergy.com)