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Try this — raises metabolism to teenage levels, raises T

Hashimoto’s is the most common cause of low thyroid function.

The disease leads to low levels of thyroid hormones — which in turn causes fatigue and any number of other maladies.

It is an autoimmune disease — this means that the body produces antibodies which attack the thyroid gland.

Lowering these antibodies is one of the main goals of Hashimoto’s treatment.

Low thyroid hormones and low testosterone frequently occur in tandem.

And researchers have just discovered that supplemental testosterone seems to lower Hashimoto’s antibodies in men with low T.

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The research was carried out at the Medical University of Silesia, Katowice, Poland. 

The findings were published in the Journal of Clinical Pharmacy and Therapeutics.

Many older doctors are aware that estrogen and progesterone can have profound effects on thyroid function in women.

But there is relatively little information on sex hormones and thyroid function in men.

“Unfortunately, no previous studies have determined whether sex hormones produce any effect on thyroid antibody titres.”

These researchers set out to determine the effects of testosterone supplementation on thyroid antibodies in men with low testosterone.

“We assessed whether testosterone affects thyroid autoimmunity in men with Hashimoto’s thyroiditis and low testosterone levels.”

34 men were recruited into the study. The men were split into 2 different groups. 

One group began supplementing with testosterone. The other group did not use testosterone, they were used for comparison.

“The patients were either treated with oral testosterone undecanoate (120mg daily) or remained untreated.”

The researchers tested hormones and antibodies before testosterone supplementation started.

All participants were tested again six months later.

“Thyroid hormones and total testosterone, as well as thyroid antibodies, were measured at the beginning of the study and 6 months later.”

Hashimoto’s antibodies remained unchanged in men who did not take supplemental testosterone.

There was a significant decrease in thyroid antibodies in the men supplementing testosterone.

“Testosterone undecanoate reduced thyroid peroxidase and thyroglobulin antibodies.”

These are the antibodies used to test for Hashimoto’s disease. 

They’re often referred to as TPOAb (thyroid peroxidase antibodies) and TgAb (thyroglobulin antibodies).

“The biological hallmark of Hashimoto’s is the presence of antibodies directed against the thyroid gland, particularly TPOAb and TgAb.”

Thyroid peroxidase antibodies (TPOAb) decreased by an average of 30%. 

From 882 to 610.

Thyroglobulin antibodies (TgAb) fell from 784 to 602 =- down 23%.

The research clearly shows that testosterone supplementation could improve Hashimoto’s in men with low testosterone.

“Our findings indicate that testosterone therapy may reduce thyroid autoimmunity, at least in men with impaired activity of the hypothalamic-pituitary testicular axis.”

Thyroid antibodies can change with the seasons or with other environmental conditions. 

This makes comparisons with the control group, who were not taking testosterone, very important.

There was no significant improvement in the control group.

“The lack of changes in TPOAb and TgAb in the control group indicates that testosterone action cannot be attributed to a spontaneous resolution of thyroid autoimmunity or to seasonal fluctuations in antibodies.”

Another important aspect of this study was that it only included men with thyroid hormone levels within the normal range. 

This means the men were very unlikely to be taking supplemental thyroid hormone.

Thyroid hormone supplementation then, is unlikely to be a confounding factor in this study.

“Excluding men with low thyroid hormones minimized the possibility that the alleviation of thyroid autoimmunity is a consequence of the effect of levothyroxine (not testosterone) supplementation.”

Men with lower levels of testosterone at the outset had more benefit from testosterone supplementation.

“Testosterone induced improvement in thyroid autoimmunity inversely correlated with baseline testosterone levels.”

You should always consult a healthcare practitioner about treating and diagnosing health-related problems.

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.


The effect of testosterone on thyroid autoimmunity in euthyroid men with Hashimoto's thyroiditis and low testosterone levels