This safe supplement treats pain better than opiates

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This safe supplement treats pain better than opiates

Neuropathic pain comprises a number of different sensory problems.

It can cause burning or coldness, “pins and needles” sensations, numbness and itching, and severe pain.

Many of the treatments for neuropathic pain are ineffective.

The condition can be caused by diabetes, spinal cord injury, multiple sclerosis, and stroke.

Opiate treatments can numb these persistent sensations — but have severe side effects.

Scientists recently tested the effects of a hormone on signs and symptoms of neuropathic pain.

Progesterone is known for its anti-inflammatory and healing properties. The researchers found it was remarkably effective at treating neuropathic pain.

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The animal experiments were carried out at the Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Iran.

The results were published in Neuroscience.

Peripheral neuropathy is a major cause of neuropathic pain.

It occurs when there is damage to the peripheral nervous system.

Peripheral neuropathy affects up to 8% of the population.

Most of those people find that there are not effective treatments for this condition.

“Many treatment strategies for peripheral neuropathy are symptomatic, and are not satisfactory.”

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“Neuroactive steroids have shown their efficacy in the treatment of neurological disorders, physical injuries, aging, or demyelinating diseases.”

Progesterone is one of these neuroactive steroids. It can heal the brain and nervous system.

“Progesterone has been demonstrated to be an effective treatment for traumatic brain injury, stroke, and peripheral neuropathy in animals.”

For these reasons, the researchers were curious if progesterone could alleviate neuropathic pain caused by peripheral neuropathy.

“We investigated whether starting progesterone after symptoms are already established would alleviate the expression of nociceptive behaviors.”

Nociceptive behaviours are behaviours which indicate an increase in pain.

Pain researchers call pain sensation nociception.

The researchers created scenarios that developed neuropathic pain in rats.

A few days after the development of peripheral neuropathy the animals were given varying doses of progesterone.

“Male rats were given progesterone 12 days after chronic constriction injury induced neuropathic pain induction.”

The rats were given daily progesterone for two weeks.

“Dosing continued until day 26.”

The animals were tested for pain responses before they developed neuropathic pain.

Those tests were repeated after the animals developed neuropathic pain, and again after progesterone treatment.

“Behavioral tests were done immediately before surgery (day 0) and on days 12, 26, 28, and 35.”

Progesterone reduced some of the key symptoms of neuropathic pain.

“Progesterone reduced both the thermal hyperalgesia and mechanical allodynia.”

Thermal hyperalgesia is a painful sensation in response to pretty moderate temperatures.

Allodynia is a painful response to a rather mild physical touch.

Progesterone decreased the extreme reaction to temperature change and touch in the animals with neuropathic pain.

The researchers also tested the muscle responses of the animals. They looked at the electrical currents going through the muscles in response to contact.

Electrical impulses can tell us a lot about how much pain the animal is feeling.

Progesterone reduced electrical impulses in the animals in response to contact with objects. 

Clearly indicating decreased pain after progesterone therapy.

“Progesterone therapy induced a significant recovery of all electrophysiological changes.”

Progesterone was effective in decreasing physical and electrical indicators of pain well after neuropathic pain had been established.

“Progesterone therapy when symptomatology is already established and continuing for a sufficient period of time may have a therapeutic effect.”

The study reinforces prior research showing the healing effects of this anti-inflammatory hormone.

This research used pretty large amounts of progesterone. You should always consult a healthcare practitioner about the proper therapeutic use of hormones.

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the xanax totem pole to ensure accuracy.

Effects of progesterone on neuropathic pain responses in an experimental animal model for peripheral neuropathy in the rat: A behavioral and electrophysiological study

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