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Dietary phosphate has increased massively in the last few decades.
The increase in phosphate is largely from fast foods and other processed foods.
Population studies have shown associations between higher phosphate and a higher risk for cardiovascular disease.
High phosphorus also creates fibrosis, including penile fibrosis. It’s very bad.
But there have been relatively few human studies looking directly at the effect of increased dietary phosphate.
This recent human study shows that phosphate can quickly increase blood pressure in otherwise healthy people.
Researchers from the Department of Medicine, University of Basel, Switzerland did this study. The Journal of the American Society of Nephrology published the results.
Population studies indicate that a higher phosphate intake leads to greater risk of cardiovascular disease and death.
“Despite epidemiologic evidence for increased cardiovascular morbidity and mortality associated with phosphate in humans…”
But the researchers could not find any intervention studies on the effect of phosphate on blood pressure.
“…no controlled phosphate intervention studies of systemic hemodynamics have been reported.”
So the researchers designed a study to see the effect of increased dietary phosphate.
20 young people participated.
The researchers put one group on a high-phosphate diet.
They put the other group on a low-phosphate diet.
“We conducted a study in 20 young adults randomized to high phosphate or low phosphate for 11 weeks.”
The study looked at changes in blood pressure and endothelial function.
“Outcome parameters were 24-hour blood pressure, pulse rate, biomarkers, and measures of endothelial and arterial function.”
The high phosphate diet was successful in raising levels of phosphate in the blood.
“Compared with the low-phosphate diet group, the high-phosphate diet group had a significant increase in blood phosphate concentration.”
And, indeed, high dietary phosphate led to higher blood pressure.
“The high-phosphate diet group had a significant increase in 24-hour systolic and diastolic blood pressure.”
Systolic blood pressure increased by an average of about four points.
Diastolic blood pressure increased by an average of three points.
Three to four points may not seem a lot.
But this was a very short-term effect in young healthy people.
The long-term effect of a high-phosphate diet on blood pressure could be much more extreme.
High phosphate also led to increased pulse rates and higher levels of stress hormones.
“…high-phosphate diet group had a significant increase in pulse and urinary metanephrine and normetanephrine excretion.”
Those two stress hormones (metanephrine and normetanephrine) are believed to have increased the pulse rates of the participants.
But they can also cause abnormal heart rhythm and anxiety.
The study didn’t find any short-term changes in endothelial function.
“Neither high- nor low-phosphate diet affected endothelial function or arterial elasticity.”
The study also looked at the effect of vitamin D.
Vitamin D can increase the amount of phosphate absorbed in the gut.
But vitamin D is also associated with a lower risk of cardiovascular disease.
“Higher vitamin D levels are associated with better cardiovascular outcomes, but vitamin D increases intestinal phosphate absorption.”
They gave the participants a blast of 600,000 units of vitamin D. And that is more than enough to find a problem if there were one.
The study found that supplementary vitamin D had no negative effect.
“Vitamin D had no effect on any of these parameters.”
Dietary phosphate could have a significant effect on blood pressure in otherwise healthy people.
“Increased phosphate intake (controlled for sodium) significantly increases blood pressure in part, by increasing sympathetic adrenergic activity.”
The results of this experiment could explain the population data showing links to high phosphate and cardiovascular disease.
Meat and grains are high in phosphate.
Fruits and vegetables are low-phosphate options.
Calcium also seems to protect against some of the effects of phosphate.
So the calcium/phosphate ratio may also be important.
This explains why dairy foods seem to be safe even though they are high in phosphate.
Many men take safe calcium supplements to increase their calcium levels so they are higher in calcium than phosphorus.
Eggshell calcium is a good way to do this.
You should always consult a healthcare professional about treating and diagnosing health problems.
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- A Controlled Increase in Dietary Phosphate Elevates BP in Healthy Human Subjects http://jasn.asnjournals.org/content/29/8/2089