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Getting Up Too Early and Missing Sleep Can Kill Testosterone 

Sleep destroys our body’s ability to make steroid hormones — including testosterone.

And even glucose tolerance can become severely impaired if you have to get up early a few days in a row, or go to bed too late…

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This human research was carried out at the Department of Medicine at the University of Chicago. The results were published in The Lancet.

Sleep debt is defined as not getting enough sleep in any 24-hour period. 

When people do not get enough sleep on numerous consecutive days, the effect of sleep debt is increased.

In developed countries, people are sleeping less and less. Sleep debt is becoming a more pronounced problem over time.

“Chronic sleep debt is becoming increasingly common and affects millions of people in more-developed countries.”

This study was designed to look at the effects of sleep debt on metabolism and hormonal functions.

“We investigated the effect of sleep debt on metabolic and endocrine functions.”

The study took place at a clinical research centre in the University of Chicago. 11 healthy young men were recruited to take part.

“We included 11 healthy young men aged 18–27 years, who spent 16 consecutive nights in the clinical research centre.”

Sleep debt was incurred by limiting the amount of time that the men could spend in bed every night to 4 hours.

“We assessed carbohydrate metabolism and hormonal function in 11 young men after time in bed had been restricted to 4 h per night for 6 nights.”

After the six days and nights of sleep debt participants stayed on at the research centre. They were allowed to sleep normally over another six day and night period.

The researchers compared the test results at the end of each six-day period. 

“We compared the sleep-debt condition with measurements taken at the end of a sleep-recovery period when participants were allowed 12 h in bed per night for 6 nights.”

Sleep debt affects the ability of the participants to manage blood sugar. 

After not getting enough sleep the participants suffered from blood sugar spikes after meals.

“Glucose tolerance was lower in the sleep-debt condition than in the fully rested condition.”

Poor sleep had an enormous effect on the rate of glucose clearance.

“The rate of glucose clearance after injection was nearly 40% slower in the sleep-debt condition than in the sleep-recovery condition.”

Sleep deprivation caused serious blood sugar problems in healthy young men. 

All of the men had healthy blood sugar and insulin readings when they slept properly.

“Glucose and insulin responses at the end of sleep recovery were in the normal range for young healthy men.”

But just a few days of poor sleep caused carbohydrate intolerance.

“During the sleep-debt condition, responses were consistent with a clear impairment of carbohydrate tolerance.”

The changes in blood sugar were clinically significant. 

The effect of poor sleep would lead an otherwise healthy person to being diagnosed with impaired glucose tolerance.

“In the sleep debt condition, the response to a morning standard oral glucose test would be consistent with the current diagnostic criteria for impaired glucose tolerance.”

The study shows that sleep plays a massive role in an individual’s ability to control their blood sugar levels.

“Sleep debt has a harmful impact on carbohydrate metabolism.”

Poor sleep also led to increased cortisol levels. High cortisol is associated with an increase in body fat, particularly belly fat.

The whole pattern of metabolic changes is similar to that seen in unhealthy aging.

Over the long-term, these effects would predispose to a whole host of diseases.

“The effects are similar to those seen in aging and, therefore, sleep debt may increase the severity of age-related chronic disorders.”

You should always consult a healthcare practitioner treating and diagnosing health-related problems.

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.


Impact of sleep debt on metabolic and endocrine function.