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This 1 supplement “works like an Alzheimer’s vaccine”
Curcumin is a bright yellow compound found in a number of plants, notably turmeric.
Curcumin has a number of alleged health benefits.
There have been some interesting animal studies using curcumin in dementia.
But follow-ups to these studies have often been disappointing.
One reason for this seems to be that curcumin has low bioavailability — very little curcumin gets into the bloodstream where it is eaten.
A new study may shed more light on the most effective way to use curcumin.
The study found that low doses of curcumin are much more effective at treating animal models of Alzheimer’s disease.
Low doses of curcumin work like an Alzheimer’s vaccine.
Higher doses could cause harm.
These animal experiments were carried out at the University of California, Los Angeles. The results were published in Neurobiology of Disease.
Alzheimer’s disease is associated with a buildup of proteins called beta amyloid.
These proteins cause inflammation and damage to the brain cells.
“In Alzheimer Disease accumulation of beta-amyloid initiates amyloid deposition and a complex inflammatory cascade.”
Inflammation is largely controlled by the immune system.
Curcumin has anti-inflammatory effects, and researchers believe this may be because it affects the immune system.
So researchers decided to test the effects of curcumin on inflammation, amyloid beta, and immune function.
The experiments involved the use of genetically modified mice.
These mice had their genes edited so that they would develop signs and symptoms of Alzheimer’s.
The Alzheimer’s mice were then treated with either low or high doses of curcumin.
The scientists recorded changes in inflammation and immune system function in Alzheimer’s mice.
“We report the effects of low and high doses of curcumin on neuroinflammation in transgenic mice.”
The researchers conducted a number of tests.
Some of these tests looked at what scientists call gene expression.
Genes can behave in different ways. They may be more or less active.
Supplements like curcumin can change how active the genes are.
The researchers looked at two genes which are known to affect Alzheimer’s disease.
Researchers call these genes CD33 and TREM2.
CD33 increases Alzheimer’s risk.
TREM2 decreases Alzheimer’s risk.
The researchers found that low doses of curcumin improved the expression of both of these genes.
“Low-dose curcumin decreased CD33 and increased TREM2 expression (predicted to decrease Alzheimer’s disease risk.)”
Curcumin changed the way genes behave, such that they would lower Alzheimer’s disease risk. But only when curcumin was given at low doses.
The researchers also looked at inflammation in the brain.
In Alzheimer’s disease, inflammation gets out of control.
Low doses of curcumin helped the brain to control inflammation.
“Low dose curcumin restored relationships between these gene expression and decreased expression of genes characteristic of toxic pro-inflammatory microglia.”
These effects were not seen in the Alzheimer’s mice which were given high doses of curcumin.
“In contrast, very high dose curcumin did not show these effects, and failed to clear amyloid plaques.”
High doses of curcumin made the problem of Alzheimer’s gene expression worse.
“Very high dose curcumin dysregulated gene expression relationships.”
The study found that low-dose curcumin decreased the amyloid beta proteins seen in Alzheimer’s disease.
Low-dose curcumin increased a process called phagocytosis.
This means that brain cells were devouring more of the harmful amyloid beta plaques.
This type of amyloid beta detoxification process was increased in mice and was also seen in samples of the human brain.
“Low-dose human stimulated phagocytosis of amyloid plaques in sections of the human Alzheimer’s disease brain and of the mouse brain.”
The researchers tested a whole host of other markers related to Alzheimer’s disease progression.
These tests looked at further gene expression and inflammation.
The results of these tests showed that low-dose curcumin seems to work in a similar way to the Alzheimer’s vaccine.
The Alzheimer’s vaccine was recently developed to attack the amyloid beta proteins in the brain. It seems that the right dose of curcumin may work in the same fashion.
“We conclude that curcumin is an immunomodulatory treatment capable of emulating anti-Aβ vaccine.”
The research shows that curcumin can be an effective supplement for dementia.
It also shows that the effective use of curcumin is rather complicated.
—-Important Message About Preventing Alzheimer’s—-
Has your doctor warned you about blood fat?
I’ve discovered a link between toxic blood fat and Alzheimer’s in men.
This blood fat builds up in the body, including the brain, and leaves fatty deposits behind…
And these fatty deposits turn into amyloid plaques, which cause Alzheimer’s and dementia.
So how do you stop blood fat?