Study: Simple diet tweak “prevents stroke”

Man with heart attack

This amino acid makes its way to the brain and is involved in strokes… but now QNZ-46 can prevent stroke and perhaps add 2 decades to lifespan — but is it safe?

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Study: Simple diet tweak “prevents stroke”

Scientists believe that they have discovered the cause of stroke.

Glutamate – an excitatory brain chemical – has been shown to initiate the changes that cause stroke.

This discovery has led to the discovery of a treatment that can block glutamate.

And this treatment could protect people at risk from stroke.

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These animal experiments took place at Plymouth University Peninsula Schools of Medicine and Dentistry. Nature Communications published the results.

This study looked at the structure surrounding the nerves in white matter of the brain.

A protective fatty structure called the myelin sheath surrounds these nerves. The myelin sheath is essential to brain function.

The myelin sheath can be damaged by activation of a brain receptor known as the NMDA receptor.

When overstimulated, this NMDA receptor damages the myelin.

“The myelin sheath is prone to injury associated with NMDA receptor activation.”

Scientists suspect that this damage to the myelin sheath is implicated in the damage caused by stroke.

“Myelin damage results in permanent and severe functional deficit in the white matter of the brain in ischemic stroke.”

Damage caused to the myelin sheath by the NMDA receptor is triggered by a neurotransmitter called glutamate.

Until now, scientists have not been able to find out the source of the glutamate that could theoretically cause stroke.

“The source of glutamate in this context is unknown.”

In these experiments, the scientists found that restricting oxygen (ischemia) to the brain of the lab animals led to a release of glutamate.

And scientists know that ischemia precipitates stroke.

“We found that low oxygen conditions trigger activation of NMDA receptors following the release of glutamate.”

The damage from stroke may be prevented if the release of glutamate can be stopped…

 …or if glutamate can be prevented from activating the NMDA receptor.

When blood flow to the brain is not sufficient, the brain does not get enough oxygen from the blood.

And this leads to a release of glutamate.

Glutamate stimulates the NMDA receptors, and the NMDA receptors break down the myelin that protects the nerve fibers – causing stroke.

The scientists then tested a number of drugs that can affect the NMDA receptors or affect glutamate.

One of the treatments they tested sits where glutamate would otherwise activate the NMDA receptor.

The drug QNZ 46 blocks the glutamate from activating the NMDA receptor – theoretically preventing stroke damage…

And, indeed, the scientists found that QNZ 46 effectively prevented most of the damage to the brain usually seen in stroke.

“Pre-treatment with QNZ-46 almost entirely prevented the structural changes in the brain related to stroke.”

Taking this treatment two hours before initiating a stroke prevented almost all of the damage in the lab animals.

QNZ 46 blocked glutamate – protecting the myelin sheath from damage associated with stroke.

“Further analysis confirmed the myelin protecting properties of the drug.”

The study couldn’t find any evidence of toxicity or any changes in animal behavior from the treatment.

“Treatment with QNZ-46 produced no apparent behavioral effects or acute toxicity.”

QNZ-46 also prevented the formation of damaging brain lesions in the animals.

“Drug treatment greatly reduced lesion volume and improved the performance in behavioral tests compared to vehicle-treated controls.”

These experiments suggest that QNZ-46 could be used in people at risk of stroke in order to prevent stroke.

“Preventative treatment with QNZ-46 in patients at risk of stroke may offer an alternative strategy for clinical intervention.”

QNZ 46 not only protected the white matter but it also protected the grey matter from stroke damage.

“QNZ-46 is surprising; in particular the effect in gray matter where it protected against stroke-related injury.”

These results could lead to a very useful therapy for stroke.

But it will need to be safety tested in humans first.

You should take the advice of your healthcare practitioner if you have an increased risk of stroke.

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.

Vesicular glutamate release from central axons contributes to myelin damage

https://www.nature.com/articles/s41467-018-03427-1