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—-Important Message From Lloyd Lester—-
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How to use sulbutiamine to improve memory
Vitamin B1 is also called thiamine.
And in recent years, there have been a number of thiamine derivatives created.
These include fat-soluble molecules that can deliver thiamine to places where it can be difficult to otherwise get high levels of thiamine to.
These fat-soluble versions of thiamine have been created in order to deliver vitamin B1 to the brain and nervous system and into the inner parts of the cell.
One of these is called sulbutiamine.
Sulbutiamine was developed in Japan, and is becoming more commonly used in France too.
It’s generally used to treat weakness and fatigue thought to be due to nervous system issues caused by locally low thiamine.
But human experience and animal experiments show that sulbutiamine can also protect the brain and improve memory.
The animal experiments were performed at Key-Obs S.A., Orléans Cedex 2, France. This paper was published in Progress in Neuro-Psychopharmacology and Biological Psychiatry.
Sulbutiamine was designed to get vitamin B1 into the brain and nervous system.
It is used to improve energy, decrease anxiety, improve mental focus and sports endurance.
Many users have reported improvements in memory while taking this fat-soluble form of vitamin B1.
These animal experiments were designed to see if this effect is real.
The experiments were carried out on rats that were trained to perform simple tasks of memory in return for a reward.
“The effect of a sulbutiamine chronic treatment on memory was studied in rats with a spatial delayed-non-match-to-sample (DNMTS) task in a radial maze and a two trial object recognition task.”
After the rats had proven that they had learned how to perform the memory tasks, they were split into different groups.
1 group got daily injections of sulbutiamine, another got a placebo injection of saline solution.
“After completion of training, animals were subjected for 9 weeks to daily injections of either saline or sulbutiamine.”
Sulbutiamine significantly increased performance in one of the memory tasks.
“Sulbutiamine improved memory in the object recognition task.”
Then the researchers gave the animals a treatment called dizocilpine.
This treatment was developed as an anticonvulsant, and it is also an anesthetic.
It was never brought into wide scale human use because it has major side-effects.
Some of the major side-effects of dizocilpine include inducing cognitive deficits.
Dizocilpine causes harm to the brain which decreases memory.
In the experiments, dizocilpine reduced memory in the animals given the placebo.
“Dizocilpine, impaired both acquisition and retention in the trained task in the saline-treated group.”
But the researchers found that sulbutiamine prevented the loss of memory associated with this treatment.
“But dizocilpine did not impair retention in the two sulbutiamine-treated groups.”
This fat-soluble form of vitamin B1 may generally improve memory…
…and the researchers believe it could also help with amnesia related disorders and treatment-induced memory loss.
“…suggesting that sulbutiamine may counteract the amnesia induced by a blockade of the N-methyl-D-aspartate glutamate receptors.”
The experiments show that the reports of sulbutiamine users of improved memory when taking this supplement are viable…
…and that these effects may be due to improved brain health.
Taken together, these results are in favor of a beneficial effect of sulbutiamine on working and episodic memory.”
These new derivatives of vitamin B1 are great – they can be very useful for a small number of health problems.
And the research also shows that (in many cases) very high doses of vitamin B1 are just as effective as lower doses of these new molecules.
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