Since iron buildup in the brain is a cause of Alzheimer’s, this breakthrough “adds decades of life…” according to Japanese researchers.
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Prevent iron buildup in the brain – new iron breakthrough
We don’t often come across a new type of treatment for cancer.
But scientists working at Okayama University in Japan have found that depleting the body’s iron levels can fight cancer in a way never seen before.
Lowering iron fights cancer stem cells.
Let’s take a look at this new breakthrough.
These scientists carried out their study at Okayama University Graduate School of Medicine in Japan and published in the medical journal Oncotarget.
The foundation of this research is the fact that excessive iron leads to the production of free radicals in the body.
These free radicals cause DNA damage and cell damage – and that can lead to cancer.
“Iron overload can act as a catalyst for the formation of free radicals, which may cause cancer.”
Cancer stem cells are the basis of all cancer cells.
These particular cells lead to the growth of tumors.
Cancer stem cells are particularly important in the fight against cancer because they are resistant to chemotherapy and radiotherapy.
So we need a way to destroy cancer stem cells.
“Cancer stem cells are resistant to chemotherapy and radiation therapy, and are strongly implicated in relapse after treatment.”
Scientists think the stubbornness and persistence of cancer stem cells in the face of radiotherapy and chemotherapy are a major cause of cancer recurrence.
So the study looked at the removal of iron and how this affected cancer stem cells.
“In the present study, we investigated the role of iron in the proliferation and stemness of cancer stem cells.”
The study focused on the growth or proliferation of cancer stem cells.
It also looked at the stemness of the cells – these stemness markers indicate how strongly these cells tend towards becoming cancerous cells.
The study used rodents with experimentally induced cancer.
They found that using treatments to remove (chelate) iron from the rodents led to a decrease in the cancer stem cell stemness and slowed the spread of the cancer stem cells.
“Iron depletion by the deferasirox and deferoxamine suppressed the proliferation of cells and the expression of stemness markers.”
Scientists implanted tumors into mice who were chemically depleted of iron.
And it turned out that depleting iron by using these treatments protected the rodents against cancerous changes from the implanted tumor.
“In a tumor implant model, the drug deferasirox inhibited the growth of cancer stem cells.”
The scientists concluded that iron seems to be a necessary fuel for tumor growth.
Iron is needed for the spread of cancer stem cells and also for stemness quality (their ability to become various cancerous cells).
”Iron appears to be crucial for the proliferation and maintenance of stemness of cancer stem cells.”
This study shows that iron depletion can fight cancer in a way that was completely unknown before.
“Iron depletion may be a novel therapeutic strategy to target cancer stem cells.”
This method of fighting cancer had not been shown before – even though scientists knew for quite some time that iron is associated with an increase in cancer.
A study published in Cancer Science in 2009 looked at some of the implications of iron in cancer.
In animal experiments, excess iron causes cancer.
“Iron is carcinogenic in animal experiments.”
Studies of human populations show that lowering iron through blood donation reduces the risk of cancer (and other diseases).
“A recent epidemiological study reported that iron reduction by phlebotomy decreased cancer risk in the apparently normal population.”
The study could lead to great advances in cancer treatment in the near future.
You should see a healthcare professional about diagnosing and treating serious health conditions like cancer.
Here’s the new discovery that removes excess iron and adds decades to your life
It turns out that a simple household powder holds the key to removing excess iron from building up in the brain and causing Alzheimer’s…
And this household powder is ultra cheap (it usually costs less than $5)…
- Iron depletion is a novel therapeutic strategy to target cancer stem cells http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path=21846&path=69293
- Role of iron in carcinogenesis: cancer as a ferrotoxic disease. https://www.ncbi.nlm.nih.gov/pubmed/?term=Role+of+iron+in+carcinogenesis%3A+cancer+as+a+ferrotoxic+disease