Only 10% of Asians get prostate cancer – not 40% like in the USA

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Only 10% of Asians get prostate cancer – not 40% like in the USA

The average Western diet contains a lot more fat than the average Asian diet.

In studies where they recreate diets for experimental purposes, the Western diet has more than twice the amount of fat than the Asian diet (approximately 35% vs 15%).

That gives you some idea of the difference in fat levels.

These differences in dietary fat content are associated with different levels of cancer and metastasis.

More dietary fat is associated with more cancer.

In Asian countries, about 10% of men develop prostate cancer. In Western countries, the figure is closer to 40%.

Asian men living in Western countries develop prostate cancer at a rate of about 40% as well.

So it seems the difference in cancer rates is environmental.

A new study seems to show that higher dietary fat is the environmental trigger causing increased rates of prostate cancer.

These researchers conducted their study at the Beth Israel Deaconess Medical Center in Boston, Massachusetts. The journal Nature published the results.

In the first part of this investigation, they looked at human cancer cells and a couple of genes that have been associated with changes leading to cancer.

Two genes (PML and PTEN) have sometimes been found lacking in cancerous regions.

Because PML and PTEN are sometimes missing in cancer, they are known as tumor suppressor genes.

The first discovery in this study was confirmation that these two genes are often not found in metastatic human prostate cancer.

“Here we found that PML is frequently co-deleted with PTEN in metastatic human prostate cancer.”

When they performed experiments on mice to remove one of these genes, the mice developed cancerous metastasis at a higher rate.

“We demonstrated that conditional inactivation of PML in the mouse prostate morphs some tumors into lethal metastatic disease.”

The study showed that the loss of these two genes also led to a massive increase in fat production in cancerous regions.

“We found a hyperactivation of fat production and cancer indicators when PML and PTEN were absent.”

The scientists then performed some experiments to see if the acceleration of cancer was caused by the increase in fat production.

Using a drug called fatostatin, the scientists administered a drug that blocks an enzyme called SREB.

SREB is necessary for fatty acid metabolism.

And, sure enough, blocking fat synthesis with fatostatin prevented tumors and metastases.

“Fatostatin blocked both tumor growth and distant metastasis.”

The scientists then wanted to find out if they could cause the same increase in cancer by feeding lab animals a high-fat diet.

Indeed, they found that a high-fat diet increased fat accumulation, tumors, and metastases in mice – mirroring the pattern seen in humans.

“A high-fat diet caused fat accumulation in prostate tumors and was sufficient to drive metastasis in a mouse model of human prostate cancer.”

To summarize the study’s findings:

  • Environmental changes can lead to the loss of genes that prevent excessive fat synthesis
  • Excessive fat synthesis leads to cancer
  • Excessive dietary fat increases cancer rates in experimental animals – mirroring the population data in humans

“Our findings support the notion that Western high-fat diets can promote metastasis.”

The scientists tested the high-fat diet because of previous associations showing that an increase in dietary fat led to higher rates of fat synthesis in the body.

After all, fat leads to more fat.

“High fat diet feeding stimulates the expression of genes encoding fat creating enzymes, and causes fat accumulation.”

It seems that eating a lower fat diet may be beneficial for health in many ways.

Other studies indicate it may also be healthier to spread fat intake out over the day rather than taking in large amounts in a short period.

You should see a healthcare professional for diagnosis and treatment of cancer.

—-Important Message—-

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Men can have a prostate the size of a lemon…sometimes even larger…

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  • This often overlooked fat-soluble vitamin lowers prostate inflammation… And it is the key to great prostate health because it naturally lowers harmful estrogen in men which causes the prostate to swell up… So no more prostate inflammation. This vitamin also boosts libido, so men feel a burst in sex drive.
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  • The best first steps to take if you’re diagnosed with prostate cancer… This Prostate Solution Bible reveals everything you need to know about the Gleason score and why it’s really important. So even if you get diagnosed with prostate cancer, you will know when “watchful waiting” is best, instead of surgery or chemo… (hint: almost always)

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.
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