Nitric oxide damages the cells and can cause fibrosis

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Today’s newsletter will be of special interest if you are taking a “male supplement” that includes L-citrulline or L-arginine in it.

These compounds increase nitric oxide in the body.

So, is this good or bad?

Nitric oxide is the darling of the giant pharmaceutical corporations.

And no wonder.

They make $5 billion a year selling ED medications that increase nitric oxide in the body.

But there is a very dark side to nitric oxide.

It’s one of the primary causes of fibrosis in the penis, liver, and more.

Plus, the nitric oxide side effects reach all the way down to the cellular level.

First, we need to understand that nitric oxide does serve a purpose in the body.

I have compared it many times to an ambulance.

It is the ambulance the body uses only when there is no other choice available.

But that is the only time the body uses nitric oxide.  It’s the last resort only.

We do not want high nitric oxide levels. We want low nitric oxide levels.

If you remember that nitric oxide is a primary cause of eye-burning smog, you get the idea.

So, how does nitric oxide causes damage?

In this study, they determined why nitric oxide is so damaging in the body.

To find out just how damaging it is, you have to realize that the crux of life is the generation of energy.

And you need to remember that the mitochondria found in virtually every cell of the body generate the energy.

Mitochondria are so important that they even have their own DNA.

Called mitochondrial DNA.

Do you remember your studies of the cell from high school?

Then you should remember that the center of the cell, the nucleus, supposedly has all the DNA that determines everything that goes on in the cell and the body.

But you may not have been told that DNA is also present and active in each mitochondria.

And cells like muscle cells may have thousands of mitochondria in each cell.

It turns out that nitric oxide damages this mitochondrial DNA.

And it damages it severely.

What you need to understand is that the mitochondria already become very damaged and compromised as we age.

Think about diseases such as diabetes, heart disease, high blood pressure, and prostate inflammation.

Every disease like this is a disease ultimately of the mitochondria.

So, it’s not a good thing for the mitochondrial DNA to be damaged by nitric oxide.

On a small group of mitochondria, the nitric oxide caused lesions.

It doesn’t seem like much, but it adds up — especially since these lesions were not always repairable.

Most of the lesions produced by nitric oxide were repaired rapidly. However, there appeared to be a subset of lesions which were repaired either slowly or not at all by the mitochondria.

Now, we know how nitric oxide produces its damage.

And that damage is far-reaching — it affects virtually every cell exposed to nitric oxide.

And when the mitochondria are damaged, they are unable to provide energy and the cell may die.

This cell death may cause fibrosis such as penile fibrosis, or fibrosis in the heart, kidneys, or liver.

This is why you should be very careful about anything that increases nitric oxide.

It can be very harmful, and you should not increase your nitric oxide.

Instead, you should strive to lower it.

Nitric oxide-induced damage to mtDNA and its subsequent repair
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC148736/
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