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Researchers: “The milk we drink today is quite unlike the milk our ancestors drank.”
—–Important message—–
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Memory problems from dairy products?
The process of forcing milk through a screen at high pressure has been used since 1919.
This reduces the diameter of milk fat globules from about 15·μm to 2·μm.
The original intent was to keep the milk from separating out into cream and other components.
Although this process leads to a better-looking milk aisle in the grocery store, it is not entirely without consequence…
Experiments have shown that milk proteins can become encapsulated inside these newly formed liposomes. And this can keep them from being digested.
Not only that, but liposome-encapsulated milk proteins can be persorbed into the body whole.
(Persorption is the deep penetration of a liquid into a highly porous solid, such as food through the gastrointestinal membrane.)
Foreign proteins that are allowed into the bloodstream are often recognized as antigens by the immune system. Antibodies can form in response.
Any peptide over about ten amino acids in length can have an antibody raised against it.
Although antibodies effectively protect us from invading microbes, their formation against food proteins is pointless and sometimes detrimental.
Since the human body cannot discriminate between a bacterial or a food protein, it will often make antibodies against both.
Immune B cells lack the ability to discern protein provenance.
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Although the vast majority of antibodies are harmless, they can become pathological if they also bind to bodily proteins such as receptors.
Antibodies that bind both the antigen and the host are termed autoantibodies:
These are the basis of many autoimmune diseases such as myasthenia gravis and diabetes type I.
Although wheat gliadins indisputably cause more autoimmune diseases than any other food protein, the peptide that causes cerebral folate deficiency is found in milk from cows.
This can lead to brain folate deficiency, dementia, and autism.
Homogenization alone is likely to blame for this – it facilitates the absorption of a protein that would otherwise be safely broken down.
This article (below) explains why cerebral folate deficiency is a big deal – and also how one particular protein in cow’s milk causes it.
“As far as we know, milk is the only food which, by homogenization, artifactually creates enzymes in liposomal form capable of being persorbed by the intestinal mucosa.”
These autoantibodies are more common than you might imagine…
Yet we still have a large variety of milk products left to choose from that are safe in this regard, such as goat’s milk.
There are even a few antidotes against cerebral folate deficiency and autoantibodies…
In the early 1970s, it was proposed that xanthine oxidase from homogenized cow’s milk leads to atherosclerosis.
Although this hypothesis is highly dubious, it has led to a fair amount of research into how homogenization encapsulates proteins and then facilitates their absorption.
This is one such study…
Although it fails to prove the atherosclerosis hypothesis, it demonstrates what the homogenization process can do.
The scientists used both raw milk and a store-bought homogenized brand.
They compared the enzyme activities of the two kinds of milk under certain conditions.
They did this because the particular enzyme xanthine oxidase had been assumed to lead to atherosclerosis.
Using detergents that dissolve liposomes, the researchers determined that a significant amount of enzymes had been trapped inside:
You could expect other proteins to be similarly encapsulated.
They demonstrated biological plausibility in vitro, but they also went one step further and gave homogenized milk to humans.
Within hours after ingestion, bovine xanthine oxidase could be found in the subject’s leukocytes (their white blood cells):
“Preliminary milk-loading experiments conducted in our laboratory have indicated that habitual milk drinkers do indeed absorb liposome-bearing bovine xanthine oxidase.”
This is an important fact to consider.
You could then expect any protein less than 290,000 daltons in size found in milk to also become encapsulated inside of homogenized milk liposomes.
Cerebral folate deficiency is caused by a milk protein having the molecular mass of 27,922·Da.
This is ten times smaller than bovine xanthine oxidase:
Enough convincing data on folate receptor autoantibodies had been compiled in the short time span since their discovery that review articles are now being written about it.
Folate receptor autoantibodies were discovered around 2004 in the pursuit of figuring out why mothers with normal folate levels had children with folate-dependent birth defects.
Yet these antibodies are relevant to more than just pregnant white females; they apply to all ages, sexes, and races.
Folate receptor autoantibodies can be created when cow’s milk folate receptors get into the body…
This can block the folate receptor on the blood-brain barrier and reduce brain folate uptake.
Folate receptors are exfoliated from cell membranes into the plasma, eventually making their way into the milk.
Although no longer functioning as a “receptor,” these soluble forms in plasma and milk still retain the name “folate receptor” because that is their official designation.
Folate receptor autoantibodies can lead to dementia in at least two ways:
(1) Folate is necessary for DNA synthesis everywhere, including the brain
(2) These antibodies also block brain biopterin uptake, which is necessary for dopamine synthesis
Although the most extreme effects are observed in growing children, adults too could expect a reduction in brain function.
Folate receptor autoantibodies – of the blocking type – increase in prevalence as a function of age.
This ranges from about 2% in children, through 10% in adults, and up to 25% in older adults:
And these are just the blocking autoantibodies, which says little about the autoantibodies that bind without actually blocking.
These binding – yet not blocking – autoantibodies can still attract attacking immune cells…
And these can lead to significant destruction of the brain areas necessary for folate uptake.
In Irish females ranging between the ages of 21 and 73, the prevalence of folate receptor autoantibodies of any type was 42%.
This approaches the prevalence in people who drink homogenized milk.
Homogenized milk is also used to create cheese, yogurt, and sour cream.
Because homogenization is not perceived as a safety issue but merely one of esthetics, labeling is not required by law.
So you’re not going to read “pasteurized homogenized part-skim milk” on a carton of milk.
Yet milk products from sheep and goats are entirely free of these problems.
Folate receptors in the milk of these species are dissimilar enough that, even should antibodies form, they would not cross-react with the human brain receptors.
You might also expect that raw milk cheeses would be safer.
Although the formation of autoantibodies from raw cow’s milk is still theoretically possible…
…the fact that these antigens aren’t protected inside of liposomes should make the possibility less likely.
Supplements such as L-methyltetrahydrofolate and folinic acid are partial antidotes for these autoantibodies…
BUT these do nothing about the tetrahydrobiopterin that is also blocked.
Folinic acid can bypass brain folate receptors altogether, entering the brain through the reduced folate carrier.
Tetrahydrobiopterin is more expensive and harder to come by.
“The results indicate that a major physical alteration by a technological manipulation of a basic food may have far-reaching biological significance.”
Although there are a few separate causes of dementia, all having their own distinct causes, the presence of folate receptor autoantibodies is certainly one to consider.
Aluminum, low sulfate, low DHA, and the persorption of dry starch particles have all been shown to lead to dementia.
However, only the folate receptor autoantibody can rightly explain the correlations observed between dementia and brain homocysteine in milk-drinking populations.
Improving digestion and taking supplemental folates should help counteract this, yet avoiding homogenized milk altogether is also an option.
Goat & sheep products are entirely safe in this regard.
—–Important Message——
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