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Makes You Cancer-Proof?
In studies, rats on a high-fat diet become obese and have a decreased ability to get rid of cancer-causing cells.
But, aspirin can increase the removal of these cancer cells. Check out this study:
These researchers conducted their animal studies at the Hokkaido University in Japan and published their results in the journal Cell.
This research centered around a type of cell known as RasV12.
These cells increase tumor formation – and they can lead to cancer.
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Normally, your body can detect the cancer-causing RasV12 cells and expell them.
“RasV12 cells are eliminated from epithelia in vitro and in vivo.”
Epithelial cells (the cells on the outside of our organs) remove RasV12 cells.
This layer of epithelial cells has a natural anti-cancer property.
“These data imply a notion that normal epithelia have anti-tumor activity that does not involve immune cells.”
The scientists wanted to find out what could affect this natural tumor process.
“It remains unknown whether environmental factors – such as obesity, aging, and infection – affect this epithelial defense against cancer.”
Obesity increases the risk of certain types of cancers.
“Obese individuals have a higher incidence of certain types of malignancies – including colon, pancreatic, and breast cancer.”
The scientists wanted to see if obesity affects RasV12 cells in rodents.
“It remains elusive whether and how obesity is also involved in tumor initiation.”
Scientists fed some mice on normal mouse food. They fed another group of mice a high-fat diet that is very well-known to cause obesity in mice.
“We examined whether obesity affects epithelial defense against cancer by analyzing the effect of high-fat diet treatment on the fate of RasV12 cells.”
Mice fed a high-fat diet had a decreased ability to remove the cancer-related RasV12 cells.
“In the small intestine and pancreas, the high-fat diet treatment significantly suppressed the removal of RasV12 cells.”
Consequently, these problematic cells build up in the organs of the animals.
“RasV12 cells more frequently remained within the epithelium.”
This effect was not systemic.
The high-fat diet had no effect on the levels RasV12 in the lungs of the mice.
“HFD treatment did not significantly affect the frequency of the elimination of RasV12 cells in the lung.”
The scientists then gave some of the mice supplemental aspirin.
They were curious about how aspirin’s anti-inflammatory properties might affect these processes – since aspirin seems to lower the risk of some types of cancer.
Aspirin is particularly well known for lowering the risk of colorectal cancers.
Aspirin had no effect on RasV12 cells in mice fed a normal diet.
“Treatment with aspirin did not significantly affect the frequency of RasV12 removal in mice fed a normal diet.”
However, aspirin increased the removal of tumor-forming cells in mice fed a high-fat diet.
“Aspirin treatment substantially increased RasV12 removal – and fewer RasV12-transformed cells remained within intestinal and pancreatic epithelia in mice fed a high-fat diet.”
Aspirin can increase natural anti-cancer defenses.
“These data demonstrate that suppression of chronic inflammation can facilitate the elimination of transformed cells from epithelial tissues.”
The study also indicates that aspirin can protect against some of the detrimental effects of a poor diet.
The scientists believe that other factors can affect the removal of RasV12 cells, altering cancer rates.
The lead author of the study believes that infection, smoking, and sleeping patterns may all affect cancer rates by slowing the removal of RasV12 cells.
And always remember that high doses of aspirin can cause bleeding and other problems.
You should see a healthcare professional about treatment and diagnosis of cancer.
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https://www.cell.com/cell-reports/fulltext/S2211-1247(18)30480-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124718304807%3Fshowall%3Dtrue
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