And no, it’s not estrogen OR testosterone
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Lowering this 1 hormone can stop prostate cancer
Much of the treatment for prostate cancer is based on the theory that the disease is caused by male hormones (androgens) and their receptors.
But some advanced forms of prostate cancer do not respond to treatments aimed at these factors
“Despite decades of research and extensive funding, an effective treatment for androgen-independent prostate cancer still does not exist.”
This may be because there are other elements involved.
One line of research has pointed toward a hormone called prolactin.
Recently, doctors terminated advanced prostate cancer for the first time using prolactin lowering medication.
This human research was carried out by the University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, USA. The summary of prolactin in advanced prostate cancer was published in Oncology.
Scientists believe that early-stage prostate cancer depends on androgen receptor signaling.
The androgen receptors are responsible for the actions of male hormones on the cell.
Prostate cancer therapies are based around depriving the androgen receptors of the male hormones.
This is known as androgen deprivation therapy.
But at least some forms of prostate cancer do not respond to androgen deprivation therapy.
This leads to a diagnosis called androgen-independent prostate cancer.
The advanced form of this type of prostate cancer, as yet untreatable, results in over 1 million deaths per year.
“Androgen-independent advanced prostate cancer continues to account for most of the ~30,000 prostate cancer deaths/year in the U.S. and ~1.2 million prostate cancer deaths/year worldwide.”
A diagnosis of androgen independent advanced prostate cancer generally leads to death within five years.
“Its cause has been unknown, and a treatment did not exist.”
Researchers had been trying all sorts of techniques targeting the androgen receptors…
…but all of these attempts failed to produce treatment.
“Prevailing views have mistakenly implicated impaired androgen receptor activity in the development of androgen-independent malignancy; which has deterred the existence of an effective treatment.”
In the last few years, some researchers have found a very strong link between the hormone prolactin and this type of prostate cancer.
“We discovered that prolactin promotes the development and progression of androgen independent malignancy following androgen ablation treatment.”
If these observations are correct, then the disease could be treated by lowering prolactin.
“That relationship dictates that a treatment for advanced prostate cancer should suppress the concentration plasma prolactin.”
There already exist a number of prolactin lowering treatments.
So the researchers tried out one of these on a patient with “androgen independent advanced prostate cancer.”
The treatment (Cabergoline) was effective at lowering prolactin.
“Cabergoline treatment of a patient that resulted in 88% decreased plasma prolactin.”
The doctors carried out tests looking at circulating tumor cells before and after treatment.
When cancer spreads, circulating tumor cells appear in the blood and lymphatic system.
These cells can be identified and they tell us how aggressive the cancer is.
Prior to treatment, this test indicated that the patient had less than two years to live.
“Prior to treatment, the patient’s circulating tumor cell count=5.4; which is indicative of survival for ~21 months.”
The prolactin lowering drug obliterated circulating tumor cells.
After just weeks, circulating tumor cell count was down to zero.
“After 7 weeks of treatment with cabergoline, the circulating tumor cell count=0.”
So far, the treatment has only been used in one patient.
But the researchers believe that they may have found the first effective treatment for androgen independent advanced prostate cancer.
“These relationships and treatment were successfully applied to a patient who presented with advanced prostate cancer; which is possibly the first reported case of an effective treatment that terminated advanced prostate cancer.”
The researchers believe that they have shown that lowering prolactin is essential for treating aggressive prostate cancer.
“An efficacious treatment should be targeted at inhibiting the production of prolactin to suppress the plasma prolactin concentration.”
You should always consult a healthcare practitioner about treating and diagnosing health-related problems.
—-Important Message—-
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