Killing mast cells before they lead to penile fibrosis

Turmeric powder and turmeric roots with stethoscope, natural medicine concept

Mast cells lead to fibrosis of the blood vessels which hurts blood flow everywhere in a man’s body…

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Killing mast cells before they lead to penile fibrosis

Mast cells are some of the most fascinating (and mysterious) aspects of animal physiology.

They are very specific cells which are commonly found in human tissues experiencing chronic inflammation, infection, or injury.

They contain “granules,” particles with secrete specific substances upon degranulation.

These substances include histamine, serotonin, prostaglandins, which are thought to be part of a general immune response:

“Biological functions of mast cells appear to include a role in innate immunity, involvement in host defense mechanisms against parasitic infestations, immunomodulation of the immune system, and tissue repair and angiogenesis.” – Metcalfe et al. (1997)

According to Ray Peat, PhD, they are probably agents of renewal and repair:

“I’m inclined to think of them as potential agents of tissue renewal or regeneration. I think their activation by estrogen, and quieting by progesterone, suggests that they are probably activators and guides for stem cell formation and differentiation, depending on the availability of support. Their presence in cancers has always seemed to me to indicate that both allergies and cancer are mainly systemic energy problems.”

Mast cells are commonly known to be involved in allergies, and in particular are responsible for the histamine release.

Turmeric, the very popular indian spice, has potent effects which appear to modulate the histamine release of mast cells, via its active compound, curcumin:

“The active component of turmeric is curcumin, a polyphenolic phytochemical, with anti-inflammatory, antiamyloid, antiseptic, antitumor, and antioxidative properties. Curcumin was reported to have antiallergic properties with inhibitory effect on histamine release from mast cells.” – Kurup & Barrios (2008)

Kurup & Barrios (2008) found that curcumin could lessen the allergic reaction triggered by the degranulation of mast cells:

“The effectiveness of curcumin in allergy and asthma has been further investigated using a murine model of allergy. The results indicate a marked inhibition of allergic response in animals treated with curcumin suggesting a major role for curcumin in reducing the allergic response.”

This has profound implications, because chronic activation of mast cells is possibly a fundamental driver of chronic inflammatory states and the development of fibrosis.

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A 2020 study by Soleimani et al. has shown how combining the popular treatment of photobiomodulation (red light therapy) and curcumin supplementation could significantly improve wound healing and reduce the number of mast cells.

Red light therapy is already known to improve wound-healing and prevent fibrosis.

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Combining this therapeutic approach with curcumin, which has itself been shown to have anti-fibrotic effects, is a very promising research topic with great therapeutic potential.

—-Important Message for Men—-

Check your member right now for fibrosis

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Some men have a bump, bend, or lump in their members.

You can feel yours now to see if you have one.

That’s fibrosis built up in the penile chambers, blocking off blood flow.

But here’s the thing — plenty of men won’t have this lump or bend…

But they’ll still have fibrosis.

Only severe cases result in bends, lumps, or curved members.

The good news is that penile fibrosis can be reversed, easily, using something as simple as a toothbrush



Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.

Metcalfe, D. D., Baram, D., & Mekori, Y. A. (1997). Mast cells. Physiological reviews, 77(4), 1033–1079.

Soleimani, H., Amini, A., Abdollahifar, M. A., Norouzian, M., Kouhkheil, R., Mostafavinia, A., Ghoreishi, S. K., Bayat, S., Chien, S., & Bayat, M. (2020). Combined effects of photobiomodulation and curcumin on mast cells and wound strength in wound healing of streptozotocin-induced diabetes in rats. Lasers in medical science, 10.1007/s10103-020-03053-8.

Kurup, V. P., & Barrios, C. S. (2008). Immunomodulatory effects of curcumin in allergy. Molecular nutrition & food research, 52(9), 1031–1039.

Ray Peat (2015). Email correspondence with Danny Roddy. 

Nugroho, A. E., Ikawati, Z., Sardjiman, & Maeyama, K. (2009). Effects of benzylidenecyclopentanone analogues of curcumin on histamine release from mast cells. Biological & pharmaceutical bulletin, 32(5), 842–849.

Jiang ZY, Zou L, Shi SS, Lu YR, Dong J, Yang CH, Lu YC, Dai GK. [Effects of curcumin on TNF-alpha and TGF-beta1 in serum and lung tissue of SiO2-induced fibrosis in mice]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 May;25(5):399-401. Chinese. PMID: 19426594.