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The abdominal aorta is the largest blood vessel in the abdominal cavity.
And this blood vessel can become enlarged in older men.
These aneurysms sometimes cause back or leg pain.
When they burst, they can cause low blood pressure, unconsciousness, and even death.
Abdominal aortic aneurysm is known to be associated with high blood pressure and low testosterone.
Researchers have begun to look into the relationship between abdominal aortic aneurysm and testosterone.
The research argues that low testosterone is a cause of abdominal aortic aneurysm.
The problem may be reversed with testosterone supplementation.
These researchers did animal research at the University of Tokyo in Japan. The journal Innovation In Aging published the results.
As people age, the blood vessels can become weak.
Aortic aneurysm is one of the serious health problems that results from weakening of the blood vessels.
“Abdominal aortic aneurysm is one of phenotypes of vascular aging characterized by aortic dilation with impaired arterial wall integrity.”
Studies show a link between low testosterone and abdominal aortic aneurysm.
“Epidemiological studies have shown that men with abdominal aortic aneurysm have lower serum testosterone.”
The researchers wanted to answer the question of whether low testosterone causes abdominal aortic aneurysm.
“Studies suggest a preventative role of testosterone – but underlying mechanisms are not clear.”
The researchers conducted a number of experiments on mice.
First, they looked at the effect of castration on the risk of abdominal aortic aneurysm.
Castration removes the testicles – and they are the source of testosterone.
“Testosterone deficiency was induced in some mice by castration.”
Four weeks later, they exposed the mice to a chemical that causes them to develop abdominal aortic aneurysm.
“Four weeks after castration, aneurysm was induced.”
The low testosterone mice had a much higher risk of developing an abdominal aortic aneurysm.
“Castrated mice showed remarkable abdominal aortic aneurysm formation compared to normal mice.”
Then they split the large group of mice into smaller experimental groups:
- One group was injected with inactive oil.
- Another group was given a low dose of testosterone in oil.
- The final group was given a higher dose of testosterone in oil.
Those treatments went on for about two months.
“Testosterone (5 and 10 mg/kg) or control oil was administered to abdominal aortic aneurysm-induced mice with castration for 8 weeks.”
The development of abdominal aortic aneurysm occurred alongside biochemical changes in the animals.
“We further found that inflammatory markers were increased.”
These tests show that castration and low testosterone lead to increased inflammation.
The researchers believed that inflammation was causing damage to the blood vessels – leading to aortic aneurysm.
So they gave some of the experimental mice supplemental testosterone.
Testosterone helped lower inflammation in the castrated mice.
“Testosterone administration significantly inhibited expression of inflammatory markers in the aorta.”
Testosterone deficiency causes inflammation, which seems to accelerate abdominal aortic aneurysm.
“Testosterone deficiency precedes abdominal aortic aneurysm by inflammation.”
Supplemental testosterone could stop or reverse the inflammation that causes abdominal aortic aneurysm.
“Administration of testosterone could prevent abdominal aortic aneurysm formation through inhibition of inflammation.”
The study adds to prior research showing the benefits that testosterone provides to the cardiovascular system.
Often, men don’t know that they are developing one of these aneurysms.
The signs and symptoms include pulsating pain in the abdomen, chest, lower back, or scrotum.
When the effects of abdominal aortic aneurysm are felt, the condition is considered to be high-risk.
Often, noticeable (high-risk) abdominal aortic aneurysm will be referred for surgery.
When one of these aneurysms ruptures, there is a very high chance of death.
And that is just another reason to protect and optimize your testosterone levels.
This study used testosterone supplementation, which is necessary for some men in certain situations.
But there are many ways to increase testosterone naturally – without the side effects of supplementation. Talk to your doctor about them.
You should always consult a healthcare practitioner about diagnosing and treating any health related problems.
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