How to use horse chestnut for better male blood flow

Grocery store - smiling woman shopping in supermarket, taking nuts with scoop

It works by opening up the blood vessels all over the body

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How to use horse chestnut for better male blood flow

Horse chestnut (Aesculus hippocastanum L.) is a natural compound extracted from a species of trees which has been found to have definite pro-circulatory benefits.

Horse chestnut has been used for medicinal purposes for thousands of years.

As with most herbal treatments, the full extent of its impacts has not yet been clearly established:

“Extract from seeds and bark of horse chestnut (Aesculus hippocastanum L) is used as an herbal medicine against chronic venous insufficiency. The effect and mechanism of action on veins, arteries, and platelets are not fully understood.” – Felixsson et al. (2010)

It has proven effective in alleviating the symptoms of chronic venous insufficiency (CVD)

This common disease is characterized by pooling of the blood in the veins, causing swelling and pressure on the vascular system. 

The impacts are often felt in the legs, with symptoms that include swelling, pigmentation, varicose veins, itching and others.  

“Horse chestnut seed extract appears to be a short-term treatment option in patients with mild to moderate chronic venous insufficiency (…)” – Snow et al. (2012)

Interestingly enough, horse chestnut’s effects on the vascular system appear independent from the action of nitric oxide

One of its major active compounds, β-escin, has been shown to inhibit the synthesis of nitric oxide. 

This is very important, because many natural compounds and therapies increase circulation by upregulating nitric oxide. 

However, nitric oxide synthesis is more of an emergency process, and should not be actively supported:

“The basic control of blood flow in the brain is the result of the relaxation of the wall of blood vessels in the presence of carbon dioxide, which is produced in proportion to the rate at which oxygen and glucose are being metabolically combined by active cells. In the inability of cells to produce CO2 at a normal rate, nitric oxide synthesis in blood vessels can cause them to dilate.”

In contrast to nitric oxide, carbon dioxide is the biologically protective way of increasing blood flow and resolving vascular problems:

“The mechanism of relaxation by NO is very different, however, involving the inhibition of mitochondrial energy production (Barron, et al., 2001). Situations that favor the production and retention of a larger amount of carbon dioxide in the tissues are likely to reduce the basic “tone” of the parasympathetic nervous system, as there is less need for additional vasodilation.” – (Peat, 2016)

That being said, these benefits provided by horse chestnut may not be worth it after all.

There is some evidence that its vasoconstricting effect may be driven by stimulating the 5-HT(2A) receptor. 

This receptor is a serotonin receptor, and it may be very dangerous to increase serotonin, as it is implicated in various cardiovascular disease states. 

In this regard, a life-threatening complication implicating horse chestnut has been documented.

Short term supplementation with horse chestnut may provide relief, and remains relatively safe, but it shouldn’t be seen as a long term solution. 

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.


Ray Peat. The dark side of stress (learned helplessness) (2016).


Frishman WH, Grewall P. Serotonin and the heart. Ann Med. 2000;32(3):195-209. doi:10.3109/07853890008998827

Ji DB, Xu B, Liu JT, Ran FX, Cui JR. β-Escin sodium inhibits inducible nitric oxide synthase expression via downregulation of the JAK/STAT pathway in A549 cells. Mol Carcinog. 2011;50(12):945-960. doi:10.1002/mc.20762


Felixsson E, Persson IA, Eriksson AC, Persson K. Horse chestnut extract contracts bovine vessels and affects human platelet aggregation through 5-HT(2A) receptors: an in vitro study. Phytother Res. 2010;24(9):1297-1301. doi:10.1002/ptr.3103


Methlie CB, Schjøtt J. Hestekastanje - naturlegemiddel mot venøs insuffisiens [Horse chestnut--remedy for chronic venous insufficiency]. Tidsskr Nor Laegeforen. 2009;129(5):420-422. doi:10.4045/tidsskr.09.33871

Snow A, Halpenny D, McNeill G, Torreggiani WC. Life-threatening rupture of a renal angiomyolipoma in a patient taking over-the-counter horse chestnut seed extract. J Emerg Med. 2012;43(6):e401-e403. doi:10.1016/j.jemermed.2010.11.044

Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev. 2012;11(11):CD003230. Published 2012 Nov 14. doi:10.1002/14651858.CD003230.pub4