How to tell if your iron levels are hurting your health

Good looking man in an apron cutting some vegetables to make himself a salad at home

Men have too much iron — causing this problem doctors don’t know about

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How to tell if your iron levels are hurting your health

What happens when you lower iron in a man?

Here’s what happens — and it may lead to adding decades to your life.

The full story is this…and it has NOTHING to do with Huntington’s disease — but this is what led scientists to this breakthrough about iron in men…

Let me explain…

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This research took place at multiple universities in the United States. The journal Free Radical Biology and Medicine published the results.

Huntington’s disease is known to be associated with dysregulation of iron.

Huntington’s is also associated with mitochondrial dysfunction – an impairment in the energy producing mechanism within the cell.

These two factors led scientists to investigate the iron within the mitochondria of Huntington’s disease cells.

“We studied brain mitochondria from Huntington’s disease mice and from human Huntington’s disease tissues.”

The scientists found that the mitochondria of mice and humans affected with Huntington’s disease are laden with excessive iron.

“We demonstrate here that human Huntington’s disease and mouse model Huntington’s disease brains accumulated mitochondrial iron.”

Mitochondria from the brains of mice with Huntington’s disease showed multiple problems that could be caused by iron.

For example, the mitochondria were unable to take up enough oxygen.

Oxygen is required within the mitochondria for proper energy metabolism.

If oxygen is blocked by iron, the cell cannot function properly. (And then nothing can function properly.)

“Mitochondria-enriched fractions from mouse Huntington’s disease brains had deficits in oxygen uptake and increased lipid peroxidation.”

The mouse mitochondria also showed increased lipid peroxidation – a process that destroys fats.

This damages cell membranes and creates harmful free radicals.

Lipid peroxidation leading to cellular damage requires iron.

Excessive iron can lead to excessive lipid peroxidation and this may be a factor in Huntington’s disease.

The scientists performed some experiments on mitochondria from the brains of Huntington’s disease mice.

They attempted to remove some of the iron from the mitochondria using a drug called deferiprone.

Removal of iron reversed the degenerative effects within the mitochondria of Huntington’s disease mice.

“The iron-selective chelator deferiprone reversed deficits in oxygen uptake and reversed changes in lipid peroxidation.”

When scientists tested the drug in live animals they found even more positive results.

Iron removal reversed mitochondrial damage and improved motor function in Huntington’s disease mice.

“A 10-day oral deferiprone treatment in mice removed mitochondrial iron, decreased lipid peroxidation, and improved motor endurance.”

Newborn Huntington’s mice given supplemental iron had accelerated Huntington’s degeneration.

“Neonatal iron supplementation potentiates neurodegeneration in mouse models of Huntington’s disease by unknown mechanisms.”

When young Huntington’s-type mice were supplemented with iron, it accumulated in the brain and caused the mitochondrial problems previously observed.

Supplemental iron could be harmful in cases of Huntington’s disease.

“Neonatal iron supplementation increased brain mitochondrial iron accumulation and markers of mitochondrial dysfunction.”

It may be possible to improve Huntington’s disease outcomes by limiting iron intake or removing it from the brain mitochondria.

“Bi-directional manipulation of mitochondrial iron can potentiate and protect against markers of mouse HD.”

The authors believe that lowering iron could be a treatment for this disease in humans.

“We demonstrate the significance of iron as a mediator of mitochondrial damage in Huntington’s and suggest that targeting the iron-mitochondrial pathway may be protective.”

There are medications to treat some of the symptoms of Huntington’s disease.

But there are no significant treatments and there is no “cure.”

Huntington’s disease is similar in its symptoms to Parkinson’s disease and Alzheimer’s disease.

Parkinson’s and Alzheimer’s are both associated with high levels of iron in the brain.

The authors of this study speculate that iron may be accumulating in the mitochondria of Parkinson’s and Alzheimer’s sufferers also.

If this is true, then iron restriction or removal may be a viable treatment for Alzheimer’s and Parkinson’s.

We know that excess iron is in the brains of Alzheimer’s or Parkinson’s sufferers, but we do not know if it is in the mitochondria.

“We are interested in determining if mitochondrial iron accumulation occurs in models of Parkinson’s, Alzheimer’s and brain aging.”

You should see a healthcare professional about diagnosing and treating neurological disorders.

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This method naturally removes excess iron from the brain and prevents Alzheimer’s

As you read in the article, too much iron building up in the brain can lead to Alzheimer’s or dementia.

The iron joins with other toxins to create amyloid plaques in the brain that cause cognitive decline.

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Here’s the method men are using at home to remove excess iron from the brain and prevent Alzheimer’s.

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.

Brain mitochondrial iron accumulates in Huntington's disease, mediates mitochondrial dysfunction, and can be removed pharmacologically

https://www.sciencedirect.com/science/article/pii/S0891584918301655

Scientists find excess mitochondrial iron, Huntington's disease link

https://www.sciencedaily.com/releases/2018/04/180411145107.htm