How gut problems lead to joint pain — and what to do about it

Elderly or senior man holding his wrist because of pains. Arthritis in his joints.

If you can destroy the bad endotoxins, you can naturally cure joint pain

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How gut problems lead to joint pain — and what to do about it

Rheumatoid arthritis causes swollen and painful joints.

Over time, the joints can become severely damaged and deformed.

It’s also common to have changes in red blood cell count as well as inflammation in the lungs, heart, and elsewhere.

This type of arthritis is characterized as an autoimmune disease.

The common treatments are painkillers and substances like methotrexate and hydroxychloroquine, which may slow progression a little.

Rheumatoid arthritis has 2 causal factors — low metabolism and inflammatory bacteria.

Both of these causes can be addressed — thereby improving the condition.

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The role of bacteria in rheumatoid arthritis has been known for a little while now.

In 2019, researchers at the University of Pretoria looked at the relationship between bacterial endotoxin and the condition.

Their findings were published in Mediators of Inflammation.

Bacterial endotoxin is a part of some bacteria.

You can get it from your own gut or from the outside environment (food and air).

People with leaky guts have lots of bacterial endotoxin circulating in their body.

This endotoxin triggers the immune system creating inflammation and “autoimmune disease.”

“Bacterial endotoxin has been implicated in the pathogenesis of rheumatoid arthritis by driving a systemic inflammatory response.”

This particular study was interested in seeing whether bacterial endotoxin from smoking could also increase the risk of rheumatoid arthritis.

It does.

“Tobacco products represent a potential source of bacterial endotoxin in this study cohort of rheumatoid arthritis patients, again underscoring the risks posed by tobacco usage for the development and severity of rheumatoid arthritis.”

Back in the 1990s, researchers were experimenting with antibiotics in rheumatoid arthritis patients.

They found that the antibiotic minocycline could improve symptoms and lab results for rheumatoid arthritis.

At the time they didn’t quite know why.

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This human study was carried out at the University Hospital Leiden, The Netherlands.

The results were published in the journal Arthritis and Rheumatology.

The treatment trial included 80 people with the inflammatory disease. They were randomly split into 2 different groups.

One group was given the antibiotic minocycline for 26 weeks.

The other group was given an inactive placebo.

“Minocycline or placebo was administered in a 26‐week, randomized, double‐blind study to 80 patients with active rheumatoid arthritis.”

The antibiotic led to significant improvements in the disease.

“There was a statistically significant improvement in the minocycline group over the placebo group. There was a pronounced improvement in laboratory parameters of disease activity.”

The researchers concluded that this antibiotic could be helpful for people with rheumatoid arthritis.

“The results of the present study suggest that minocycline is beneficial and relatively safe in rheumatoid arthritis patients.”

A year later, American researchers conducted a longer trial with even better results.

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This human study was carried out at the Henry Ford Health Sciences Centre in Detroit, Michigan.

219 participants were recruited. The research took place in six different centres across the United States.

This was a high quality double blind, randomised, 48 week trial. Almost twice as long as the previous trial.

The participants were randomly assigned to either minocycline or an inactive placebo.

“109 and 110 patients were randomly assigned to receive minocycline and placebo, respectively.”

The antibiotic minocycline improved swelling and tenderness.

“At 48 weeks, more patients in the minocycline group than in the placebo group showed improvement in joint swelling and joint tenderness.”

The antibiotic improved labs used to assess rheumatoid arthritis.

“The minocycline group also showed greater improvement in hematocrit, erythrocyte sedimentation rate, platelet count, and IgM rheumatoid factor levels.”

Minocycline was not associated with an increase in side effects compared with the inactive placebo.

The researchers concluded that this antibiotic could safely improve clinical and functional parameters of rheumatoid arthritis.

“Minocycline was safe and effective for patients with mild-to-moderate rheumatoid arthritis.”

Minocycline and other similar antibiotics have the ability to lower inflammatory bacterial endotoxin — because they kill the gut bacteria which produce it.

Minocycline lowers bacterial endotoxin — which has an anti-inflammatory effect.

But the mechanisms were a mystery to the researchers. 

“The mechanisms of action remain to be determined.”

For some reason, endotoxins are largely ignored even though there is an enormous amount of data showing it is a systemic poison.

You don’t need to use chemical antibiotics to lower endotoxins.

There are a number of powerful dietary and supplemental methods which are just as effective.

You should always talk to your doctor about using chemical substances to treat health problems.

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.


Tobacco-Derived Lipopolysaccharide, Not Microbial Translocation, as a Potential Contributor to the Pathogenesis of Rheumatoid Arthritis. 


Minocycline in active rheumatoid arthritis. A double-blind, placebo-controlled trial. 


Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial. MIRA Trial Group.