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—-Important Message From Jeff—-
This is pretty shocking… (watch at your own risk, NSFW)
As soon as you watch this video — a new way to get a thicker, girthier and bigger member…
Can this tablet make your deepest darkest fears melt away?
Propranolol is a beta blocker treatment used for heart conditions, high blood pressure, migraines, and anxiety.
It has numerous effects, including blocking adrenaline receptors.
A recent study shows how this treatment, combined with psychological techniques, can be very effective at reducing phobias.
The human research was carried out at Amsterdam Brain and Cognition, University of Amsterdam in The Netherlands. This paper was published in Biological Psychiatry.
Phobias consist of a fearful memory linked to a stress response.
Not long ago phobias were thought to be incurable in some scientific circles.
But recent research has proven this to be untrue…
“Fear memories are no longer considered as indelible entities.“
Recent experiments showed that the fear memory element of phobias have to be effectively rebuilt in the brain every time the phobia is experienced.
“During past years, it was rediscovered that retrieval of a consolidated fear memory may instigate a protein synthesis– dependent restabilization process called reconsolidation.”
Of course, if something has to be rebuilt then you can interrupt the rebuilding.
Researchers used this idea to design a method using treatments to try to reduce phobia.
“Pharmacological disruption of this process enables the modification of a previously acquired fear memory.”
The researchers decided to test out the theory on a number of people who had a pretty severe phobia of spiders.
This is a common and often long-lived phobia.
“Given that older and stronger memories are generally more resistant to change, we tested whether disrupting reconsolidation would also diminish fear in individuals who had developed a persistent spider fear outside the laboratory.”
Reconsolidation is the process of remembering the fearful event, triggering proteins in the brain to rebuild the structures that store the memory.
The researchers carried out experiments on these people using behavioral techniques…
… as well as the beta blocking treatment propranolol or an inactive placebo.
There were 15 people in each group.
“Spider-fearful participants received a single dose of 40 mg of propranolol , double-blind and placebo-controlled, after a short 2-min exposure to a tarantula.”
The experiments ran like this:
Participants were asked to approach a baby or adult tarantula in a small room.
They were marked according to how close they got to the spider, which was in a jar in the case of the small spider, or a cage in the case of the adult.
They were also marked on their fear ratings of the experience right after the event.
The participants first had an experience with the baby tarantula.
A few days later they were asked to approach and touch the large spider after talking to someone about their phobia – reactivating their fear memory.
Right after this second experience, they were given 40mg of propranolol or a placebo.
They were then retested 4 and 9 days later, after 3 months and after 1 year.
This experiment tested their baseline, reactivated their fear memory, put them in a major phobia situation, immediately gave them propranolol…
…and then retested them a few times to see if there was any effect on phobia.
The researchers also tested a group who approached the large spider and had a dose of propranolol but did not talk about their fear memory first.
In other words they did not reactivate their fear memory.
“To test whether memory reactivation was necessary to observe a fear-reducing effect, one additional group of spider-fearful participants (n = 15) received a single dose of 40 mg propranolol without memory reactivation.”
The results were positive.
Only people who had been given propranolol after reactivating their fear memory got closer to the spider in the later tests.
“Disrupting reconsolidation of fear memory transformed avoidance behavior into approach behavior in a virtual binary fashion.”
You can see the higher scores for the green dots above.
These green dots were people who talked about and reactivated their fear memory BEFORE experiencing the approach to the large spider and then taking propranolol.
The effect remained even 1 year after the single dose of propranolol given at the appropriate time.
“The effect persisted at least 1 year after treatment.”
It shows that memories do need to be rebuilt or re-consolidated every time the phobia is experienced, and that these rebuilding processes can be interrupted with propranolol, reducing the phobia.
The participants didn’t initially believe that the treatment had worked. But the later behaviors showed it had.
“Interestingly the ‘treatment’ did initially not affect the self-declared fear of spiders but instead these reports followed the instant behavioral transformation several months later.”
The findings cast aside a lot of the theoretical basis for psychological therapy used over the last few decades.
Using a stress reducing substance at the right time can quickly improve major psychological and brain problems.
“A new wave of treatments that pharmacologically target the synaptic plasticity underlying learning and memory seems to be within reach.”
You should always consult your healthcare practitioner for guidance on medical diagnosis and treatment.
—-Important Message for Couples—-
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