Do this – it triggers immediate desire in your wife or gf

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Do this – it triggers immediate desire in your wife or gf

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Yes, I’m talking about YOUR woman…

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Newly discovered bug the real cause of rheumatoid arthritis?

I previously reported on some interesting research on rheumatoid arthritis.

This included findings that:

  • Certain antibiotics seem to help with the condition.
  • Smoking is associated with the disease (smoking delivers bacterial particles via the smoke).
  • Leaky gut is associated with rheumatoid arthritis.

All these facts point toward a bacterial cause of the disease.

Well, researchers may have finally identified the bacteria which causes rheumatoid arthritis.

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The human research was carried out at University of Colorado Anschutz Medical Campus in Aurora. This paper was published in Science Translational Medicine.

There is a very old idea about the origins of rheumatoid arthritis and that idea is that the disease is caused by a sort of infectious illness.

This theory has been sidelined for a long time.

It proposes that this infection originates at the mucosa – the skin and tissues that line the inside surface of different parts of the body.

We now know that rheumatoid arthritis is an autoimmune disease triggered by antibodies.

But this does not completely rule out the mucosal origins hypothesis.

“The mucosal origins hypothesis of rheumatoid arthritis (RA) proposes a central role for mucosal immune responses in the initiation or perpetuation of the systemic autoimmunity that occurs with disease.”

In this study, the researchers carried out an analysis of antibodies in people at risk of rheumatoid arthritis.

These are people who carry antibodies related to rheumatoid arthritis.

The RA antibodies can show up in the mouth, lung and gut many years before any symptoms of rheumatoid arthritis begin.

These antibodies were compared against antibodies to various different types of bacteria.

The researchers found a striking similarity between rheumatoid arthritis antibodies and antibodies related to 2 different families of bacteria.

In the human body, bacteria populate the mucosal regions, the skin, the eyes, the nose – but particularly the gut.

“We identified cross-reactivity between RA-relevant autoantigens and bacterial taxa in two closely related bacterial families.”

The researchers then discovered some of these bacteria in the human digestive system via stool analysis.

The researchers then confirmed that these bacteria cause an autoimmune response in people at risk of rheumatoid arthritis.

“After generating bacterial isolates within the Subdoligranulum from the feces of an individual, we confirmed monoclonal antibody binding and CD4+ T cell activation in individuals with RA compared to control individuals.”

The researchers then gave some mice a dose of this bacteria and found it produced an immune response in the joints similar to that found in rheumatoid arthritis.

The suspect bacteria also produced joint swelling – the physical manifestation of the disease.

“When Subdoligranulum isolate 7 colonized germ-free mice, it stimulated TH17 cell expansion, serum RA-relevant IgG autoantibodies, and joint swelling reminiscent of early RA…”

On top of this the researchers also found rheumatoid arthritis antibodies in the joints of the animals which had been given the suspicious bacteria.

“…with histopathology characterized by antibody deposition and complement activation.”

It seems that these researchers have identified the bacteria which trigger the immune system reaction that leads to rheumatoid arthritis.

If correct, and if this is the sole cause of rheumatoid arthritis, then all that remains is finding the safest and most effective way to eliminate this bacteria in people at risk of the disease.

We already know that some antibiotics like minocycline can be very effective for RA symptoms.

It’s possible that eliminating this bacteria could put the disease in remission for people who already have joint inflammation.

The research also supports the old hypothesis that RA begins in the mucosa – as this is where these bacteria live!

“These findings demonstrate a mechanism of RA pathogenesis through which a specific intestinal strain of bacteria can drive systemic antibody generation and joint-centered antibody deposition and immune activation.”

You should always consult your healthcare practitioner for guidance on medical diagnosis and treatment.

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.
Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum