Do low levels of this hormone “cause 90% of disease”

Do low levels of this hormone “cause 90% of disease”

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Do low levels of this hormone “cause 90% of disease”?

Chronic disease, low sex drive, depression, and accelerated aging – all of these things have a connection with low testosterone levels. 

They also have a connection with inflammation.

A recent study looked at the relationship between testosterone and inflammation.

The results indicate that testosterone might be the natural and safe anti-inflammatory treatment for men.

Bianchi did his research at the Department of Nutrition and Metabolism, Clinical Center Stella Maris, San Marino and published the results in the Journal of the Endocrine Society.

Many men with chronic diseases have low levels of testosterone.

“Low plasma testosterone (T) levels correlated with metabolic syndrome, cardiovascular diseases and increased mortality risk.”

Testosterone also has a profound effect on body fat levels (that’s adipose tissue).

“T exerts a significant effect on the regulation of adipose tissue accumulation, and in the glucose and lipids metabolism.”

Adipocytes are fat cells that make up most of the adipose tissue, and these adipocytes are the source of many problems.

They (fat cells) create inflammatory agents called adipokines, which are a type of cytokine.

Cytokines create inflammation.

Put that all together and it seems that adipokines are responsible for causing disease.

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“Adipocytes are the primary source of the most important adipokines responsible for inflammation and chronic diseases.”

This research looked at the effect of testosterone on the levels of these inflammatory adipokines.

“This review aims to analyze the possible effect of T on the regulation of the pro-inflammatory cytokines secretion.”

The study looked for all previous investigations into this subject – searching Google Scholar, Medline, and Cochrane databases for relevant information.

They picked up references to testosterone, inflammation, and cytokines.

The researchers also used some of the most problematic inflammatory cytokines as keywords in their search.

“A search using the following keywords: ‘testosterone’ with ‘inflammation’, ‘cytokines’, ‘adiponectin, CRP, IL-1B, IL-6, TNFα, leptin’ was conducted.”

This search found two basic types of studies:

  • Studies looking at the effects of low testosterone
  • Studies looking at the effect of testosterone supplementation on inflammatory cytokines

“Sixteen articles related to the effect of low T level and eighteen to the effect of T therapy on pro-inflammatory cytokine were found.”

From dozens of studies, they concluded that testosterone lowers inflammation caused by body fat.

“T exerts a significant inhibitory effect on adipose tissue formation and the expression of inflammatory adipokines.”

Testosterone lowers the production of tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 (IL-1).

These are some of the most problematic inflammatory mediators.

“T has an inhibitory effect on tumor necrosis factor alpha, interleukin-6, and interleukin-1.”

Low testosterone will increase these inflammatory mediators.

AND correcting testosterone deficiency will lower inflammation.

These inflammatory markers indicate disease – and they go up with age, body fat, and low testosterone.

“An inflammatory status due to pro-inflammatory cytokines is particularly evident in the elderly – and in patients with low T level and obesity.”

These inflammatory markers also play a huge role in insulin resistance.

“Adipokines like tumor necrosis factor alpha, interleukin-1, and interleukin-6 mediate insulin resistance.”

This type of inflammation plays a huge role in cardiovascular disease.

“Higher levels of pro-inflammatory cytokine play a crucial role in the development of cardiovascular disease.”

It seems that inflammation is even a huge driver in causing cancer.

“Adipokines are involved in the development and progression of cancer.”

The study underscores the importance of healthy testosterone levels.

“A low testosterone level in men represents an important risk factor for health.”

It’s a good idea to try to increase testosterone by natural methods first.

If that doesn’t work, find a good doctor who is knowledgeable about the topic.

Unmonitored testosterone supplementation can lead to increased estrogen…

And that will make any problems you have worse.

“Testosterone’s effect is modulated by estrogen levels, which should always be tested.”

You should always consult a healthcare practitioner for the treatment and diagnosis of any health problems.

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.
The anti-inflammatory effects of testosterone 
https://academic.oup.com/jes/advance-article/doi/10.1210/js.2018-00186/5137187 

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