Candidemia – Are You Infected?

Candidemia -- Are You Infected?

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Candidemia is the number one worst but undetected infection – yet no one is talking about it. Here’s what you need to know…

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Candidemia – Are You Infected?

Most people will accept the idea that an infection can cause fatigue.

Mononucleosis and African sleeping sickness are two well-known infections with fatigue as the defining trait, one caused by a virus and the other by a trypanosome (a parasite).

In the case of yeast, we actually use the term “overgrowth” instead of “infection.”

That’s because Candida albicans normally co-exists in harmony with the other intestinal flora in most people.  

The common wording tends to downplay the link, making it seem minor – although a full-fledged “yeast overgrowth” is equivalent to an infection in every practical sense.

Medical people downplay the link even more.

Doctors, dietitians, nurses, pharmacologists, salespeople, and Big Pharma executives all minimize the importance of yeast overgrowth because they themselves are to blame for the epidemic – for the most part.

Antibiotics, corticosteroids, and bad dietary advice are the prime causes of yeast overgrowth.

Although C. albicans is the most common and the most dangerous, other species are sometimes involved.

Even Aspergillus and Saccharomyces species have been isolated…

And scientists have shown that infection with common brewer’s yeast can produce enough ethanol to make a person legally drunk (BACs between .2 and .3).

Ironically, so many people get the “chronic fatigue” diagnosis because it isn’t really something that can be diagnosed at all.

Besides fatigue, the inability to “find anything else wrong with them” is what creates this disease classification itself.

But with no reliable biochemical, histological, or radiographic parameter to help define it, “chronic fatigue” means about as much as the imaginary “always tired” syndrome.

However, there are very few commonalities in serum profiles among cases so the confusion is understandable.  

But could this lack of an official biological explanation just be a way of skirting liability for the reckless promotion of antibiotics?

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Candidemia is the number one hospital-caused infection – and we need to take it seriously.

Chronically undertreating a condition or treating it under the wrong paradigm helps the medical complex to keep making money…

And it is almost standard operating procedure – outside of the narrow field of emergency medicine.

But there’s actually a significant connection.

The popular press often uses Candida albicans and fatigue in the same sentence – and testimonials from patients confirm the ability of yeast to cause fatigue.

And studies have found this too.

In a study limited to just the symptomatic aspects, these are some of the most common symptoms reported: tiredness, decreasing strength, vegetative complaints…

Sure, “tiredness” and “vegetative state” are not exactly the same word or term as “fatigue” – but they are synonyms.

Maybe the editors of medical journals have a reason to avoid explicitly linking the word “fatigue” to C. albicans?

But seriously, candidiasis is a real phenomenon and we should think of it as such – yeast in the body can cause serious effects.

Although there are very few commonalities among the broad group of patients with “chronic fatigue,” the commonalities that do exist all strongly imply a yeast connection.

AND get this: The very same tryptophan metabolite responsible for African sleeping sickness is produced by C. albicans.

This molecule, tryptophol, is very potent.

Tryptophol also explains why tryptophan reliably causes drowsiness even though serotonin itself does not.

And that involves this missing metabolite.

Tryptophol also explains the longstanding contradictory findings in the link between fatigue – chronic or otherwise – and tryptophan.

In fact, there are many parallels between tryptophan and chronic fatigue…

Yet most studies don’t focus on this.

And the ones that do don’t measure tryptophol, only 5-HIAA/serotonin.

Many scientists and medical doctors believe that serotonin and 5-HIAA are the only indoles worth considering.

But tryptophol, which is related, is surprisingly powerful in many aspects.

…not least of which is the promotion of sleep:

Scientists have known about this molecule for over a century.

But they didn’t discover how it affects sleep until the 1960s.

They discovered oleamide thirty years later. Until then, they thought tryptophol was the most powerful endogenous sleep inducer.

(Endogenous means not having an external cause.)

“The present study does suggest that there are certain common metabolic effects of tryptophol and barbiturates…”

In this classic study, biochemists at Texas A&M University elaborated on some of the finer aspects of tryptophol.

They discovered that tryptophol has a peculiar ability to swell red blood cells to the point of explosion.

Serotonin can’t do this at the concentration used.

They showed that, among tryptophan metabolites, tryptophol is by far the most oil-soluble.

This means that it should be able to cross the blood-brain barrier more readily, and that has been confirmed.

They even replicated the earlier sleep experiments.

But this time they used a full panel of tryptophan congeners for comparison:

Of the indoles shown above, the only ones that induced sleep were 5-methoxytryptophol and tryptophol.

Serotonin normally gets most of the attention, but it failed to promote sleep.

And all tryptamine did, to this end, was to cause death in 50% of the animals… something that parents euphemistically tell children is “like going to sleep.”

Nothing really compares to tryptophol when it comes to inducing sleep.

However, despite the uniqueness of tryptophol in so many ways – and especially its obvious potential to explain chronic fatigue – this metabolite is not routinely measured.

It’s actually extremely rare even to even see this molecule mentioned in modern studies of any type, except those on trypanosomes – which cause African sleeping sickness.

“These alterations may account for the behavioral changes observed in human trypanosomiasis.”

But, besides protozoa, yeast has been found to assimilate tryptophan from its environment and convert it into tryptophol.

And scientists have known this for over a century.

Since tryptophol powerfully induces sleep, any infection that produces it can be logically supposed to cause fatigue…or tiredness and the “vegetative state.”

Candida albicans is the most common yeast pathogen and back in 1968 researchers showed that it specifically does this:

This yeast can make and excrete tryptophol, just like the protozoan parasite that causes African sleeping sickness.

“A comparison of the infrared and mass spectra of compound II with those of an authentic sample of tryptophol showed them to be identical.”

And this has been later confirmed: Candida albicans can excrete tryptophol into its growth medium at concentrations ranging up to 191 μg/mL.

But there’s even more reason to believe that tryptophol causes chronic fatigue.

Sufferers of chronic fatigue have been reported to significantly improve after antifungal treatment:

Dr. Carter, who did this study, lays down a good case for the association.

The immunological parameters present a good clue.

Chronic fatigue patients often present a characteristic cytokine profile.

That is not particularly unusual in itself. But it is also true of people with chronic candidiasis.

Even more importantly, they respond to antifungal drugs:

“Dr. Carol Jessop reported her findings in 1,100 patients with chronic fatigue syndrome at the Chronic Fatigue Syndrome Conference (April 1989). 84% of the patients had a favorable response to oral ketoconazole…”

Perhaps to avoid liability and to ensure future profits, the AMA will probably continue to ignore this link for some time to come.

But it could still become an “open secret” to the public – if it hasn’t already.

Since the “definition” of chronic fatigue is so broad, there are (of course) other causes…

For example, autoimmune antibodies and other infections will always cause a certain subset of chronic fatigue cases.

But candidiasis is quite possibly the most common causative factor.

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.
Lingappa, B. "Phenethyl alcohol and tryptophol: autoantibiotics produced by the fungus Candida albicans." Science (1969) http://science.sciencemag.org/content/163/3863/192.shortKosalec, I. "Isolation and cytotoxicity of low-molecular-weight metabolites of Candida albicans." Frontiers in bioscience (2008) https://pdfs.semanticscholar.org/5d59/a05c080a99b43897c5ee811e1307952d8918.pdfSeed, J "The biological effects of tryptophol (indole-3-ethanol): hemolytic, biochemical and behavior modifying activity." Comparative Biochemistry and Physiology (1978) http://sciencedirect.com/science/article/pii/0306449278900916Demitrack, M. "Plasma and cerebrospinal fluid monoamine metabolism in patients with chronic fatigue syndrome: preliminary findings." Biological psychiatry (1992) https://pdfs.semanticscholar.org/5f4e/4a265a27c42a7560e8b789b53481bafd3149.pdfEhrlich, F. "Über Tryptophol (β‐Indolyl‐äthylalkohol), ein neues Gärprodukt der Hefe aus Aminosäuren." Berichte der deutschen chemischen Gesellschaft (1912) http://onlinelibrary.wiley.com/doi/abs/10.1002/cber.191204501134

1: What are the symptoms of candidemia?

Did you know that Candidemia is a common yeast infection among hospitalized people?According to research studies, the percentage of people who die, among critically ill people who are infected with Candidemia fungus is estimated between 45% - 50%.Candidemia is a condition that is caused by the yeast, Candida. Over 200 forms of this yeast exist. When a person suffers from Candidemia, the yeast infection enters the bloodstream. Candida is a common yeast that normally lives in the digestive tract and on the skin of the body. As long as they are present there,i t does not pose a problem.But where Candida enters the bloodstream, this can be dangerous. Once it enters the bloodstream, Candida can infect the brain, eyes, heart and even affect the bones. The growth of Candida can also affect the liver, spleen, abdomen, kidney and the lungs tooThe symptoms of Candidemia include high fever and chills. Patients usually experience hypertension and can suffer from bouts of confusion. Depending on the specific area of infection, the symptoms may vary too. There may be abdominal pain and the presence of urinary tract infections. Other symptoms include the formation of abdominal abscesses and even anorexia. Symptoms of candidemia are dependant on the site of the infection and may also include skin lesions, shock, and even renal issues. Where Candidemia affects the eye, it can cause irreversible scarring and permanent blindness.But how does Candida get into the bloodstream in the first place?If we look at the fact that Candidemia is more susceptible to hospitalized patients, then infection from surgery is a possible reason. Candida strains that are present in the gastrointestinal tract can get disrupted during surgery. In addition, Candida strains can also get transmitted from healthcare workers, if proper sanitization procedures are absent. Some research studies show that certain conditions before surgery like renal failure, pancreatitis, and broad-spectrum antibiotic therapies, can hinder the immune system and can make the body more prone to Candidemia. IV lines and GI tracts are the commonly known areas of entry of the Candidemia fungus into the bloodstream.Candidemia can also enter the bloodstream through the intravenous catheters that are used during surgery or where a patient is recovering from an intensive condition.Not everybody is susceptible to Candidemia. But individuals who have a weakened immune system are prone to this disorder than others. If you have just had surgery or have been in the Intensive care unit, the probability of being affected with Candidemia is unusually high. Individuals who have recently had cancer chemotherapy or an organ transplant are those whose bodies are weak or have weak immune systems. They are more susceptible to Candidemia in these cases. Patients who are in the preliminary of extreme stages of AIDS are very susceptible to Candidemia too.People with Diabetes or who are suffering from a low level of White blood cell count are susceptible to Candidemia too.Earlier diagnosis plays an important role in this case, though Candidemia is treatable with oral and intravenous antifungal medications such as Amphotericin and Fluconazole. Sometimes Echinocandin, a type of antifungal medication is also recommended based on the severity of the infection and the specific location of the infection. Care is usually taken to analyze certain factors like the age and health of the infected person into consideration before starting with the medications.

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