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Their brains showed us how to prevent or reverse Alzheimer’s…
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The Astronaut Method: No More Alzheimer’s
As we age, so do our brains.
But some brains age much faster than others…
Why? Well, that’s a complicated question.
There are many factors involved when it comes to protecting the brain from aging and deterioration.
But this new animal study lends some insight into the reasons behind decreased brain performance in astronauts and the elderly.
(You have to work your legs.)
These scientists conducted their experiments at the Università degli Studi di Milano, Italy and published their results in Frontiers in Neuroscience.
Astronauts suffer from deterioration of the muscles and nervous system (including the brain) while in space.
People suffering from health conditions that limit their movement have the same problems.
These muscle restrictions lead to the deterioration of brain and nervous system health that has been linked to dementias such as Alzheimer’s and Parkinson’s.
“Both astronauts and patients affected by chronic movement-limiting pathologies face impairment in muscle and/or brain performance.”
These observations led scientists to wonder whether inactivity of certain muscle groups could be associated with degeneration of the brain and nervous system.
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Limiting movement can decrease communication between the brain and the rest of the body – and also decrease the number of new brain cells.
“Movement limitation can influence the nervous system, altering neurogenesis and the interaction between motoneurons and muscle cells.”
In this study, the researchers wanted to look at the cells that build and rebuild the brain – to find out whether limiting movement has an effect on these neural stem cells.
“Our study aims to fill this gap by focusing on the biological and molecular properties of neural stem cells.”
In order to limit the movement of the lab mice without causing them too much stress, they gently suspended the mice by their tails.
Their front legs and lower body could touch the ground, but their hind legs didn’t get used much because they couldn’t reach the floor.
“The animals were suspended in cages by a thin string tied at one end to the tail; the animals could move freely on their forelimbs.”
The study used adult male mice.
There was also a control group of mice kept in the same lab, but not suspended by their tails.
After 14 days, the scientists examined the brains of the mice.
Mice whose movement was limited had fewer brain-building stem cells.
“The motor-deprived animals had fewer proliferating cells than control animals.”
There was a massive 70% decrease in neural stem cells.
This could cause severe impairment to the brain’s ability to function.
Further studies looked at the ability of stem cells to create (proliferate) more stem cells.
Deprivation of movement also inhibited stem cell proliferation.
“Neural stem cells obtained from motor deprived mice show a lower proliferation capability.”
On top of this, the stem cells of the suspended mice had a lower chance of becoming useful brain cells.
It seems they could not develop into fully formed neurons at the same rate as in the control animals.
“Differentiation of neural stem cells from suspended mice was impaired, they do not achieve mature neuronal electrical membrane properties.”
The brain functions as a massive electronic circuit.
Inadequate electrical properties will damage brain performance.
A deficiency of movement prevents the brain from rebuilding itself properly.
“The suspended animals, which can freely explore the cage without climbing, underwent little stress – the changes in the brain are likely due to the reduced overall amount of movements, by disuse of the leg muscles.”
The animals’ hind legs were not paralyzed or taped down – so the animals could actually move their hind legs.
But they were less inclined to do so – and they did not get a proper workout when they did move their hind legs because there was no weight on them.
“The hind limbs are free to make movements but the limb muscles are not exposed to weight load and are lacking an active muscle force and strength development.”
Movement is critical for more than just the muscles.
Even some light bodyweight exercises or walking could protect the brain.
You should always see a healthcare professional if you are seeking medical advice.
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