New discovery that headache sufferers swear by

New discovery that headache sufferers swear by

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For those days when you need all the relief you can get…

—–Important Message—–

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The new discovery that headache sufferers swear by…

I’ve suffered more than my share of headaches. So I want you to know what I recently discovered.

Migraines are the main target, but this works for all types of headaches…

Migraine is an extremely debilitating disorder that produces pain, visual distortion, and disorientation.

The debilitating effect it has on sufferers is matched by its ability to evade understanding and treatment.

For decades, science has analyzed the alterations in biomarkers during migraines.

At every point where it seems that a breakthrough has been made – the science has been stopped in its tracks.

Serotonin blockers can reduce migraines in some people.

Intravenous injection of serotonin cures migraine, but the side effects of IV serotonin are unacceptable).

Scientists previously found that elevations in prostaglandins are associated with migraine.

But prostaglandin blockers didn’t work.

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Calcitonin gene-related peptide (CGRP) is elevated in migraine…

And new technology has allowed the design of a CGRP blocker.

The results are promising.

Scientists working at the Jefferson Headache Centre in Philadelphia published this human trial in the New England Journal of Medicine.

Calcitonin gene-related peptide (CGRP) is the focus of this study.

For years, scientists have known that CGRP is increased in migraine – but we’ve only recently developed the type of technology that can block it.

One of the commonalities in migraine is the vasodilation of cerebral vessels.

This means the tubes that carry blood in the brain expand.

This is associated with the pain and other symptoms of migraine. (It is unclear why.)

The experiment used a monoclonal antibody to CGRP.

This is a new immune-system-based therapy that targets the CGRP peptide.

The therapy (Fremanezumab) binds to CGRP and blocks it,  preventing vasodilation –theoretically…

The study enrolled over 1,000 patients diagnosed with chronic migraine.

These were people with headaches 15 or more days per month and migraine more than 8 days per month.

The patients were divided into three groups.

One group got the therapy every three months, another group got the therapy every month, and the last group received an inactive placebo.

The study found that both doses of the new therapy reduced the average number of headache days per month.

“Reduction in the average number of headache days per month was 4.3 with fremanezumab quarterly, 4.6 with fremanezumab monthly, and 2.5 with placebo.”

As you can see, the therapy removed four headache days per month regardless of dose frequency.

(But you can see in the quote there was also a reported decrease in headaches from the placebo.)

Over 1/3 of the patients who received the therapy had at least a 50% reduction in the number of headaches.

“The percentage of patients with a reduction of at least 50% in the average number of headache days per month was 38% in the quarterly group and 41% in the monthly group.”

So that is a similar reduction in migraine from both dose frequencies again.

To summarize: At both dose frequencies, about the same number of patients had about the same reduction in headache days and in the total number of headaches overall.

So people using this therapy may only need dosing a few times a year.

This is a promising lead in the ongoing investigation into the cause and treatment of migraine.

The reduction in migraine seen in this study is similar to that of other medications such as aspirin, cyproheptadine, and tetracycline.

Some other substances such as vitamin B2 and magnesium have also been shown to reduce migraine by the same degree…30–50%.

If the CGRP antibody treatment proves to be safe, it could lead to a very useful tool against migraine.

The side effects for the treatment groups were not much above those for the placebo group.

But more in-depth studies should be conducted.

The treatment of migraine for most people will continue to include more than one medicine or supplement…

…unless the numbers from this study can be improved in the future.

Some of the most effective migraine treatments are active on serotonin or serotonin receptors (they block serotonin).

These include LSD, psilocybin, lisuride, and sumatriptan.

All of these serotonin-targeting anti-migraine agents are problematic either legally or because of side effects – and none of them work for everyone.

Serotonin and CGRP are related in migraine but it’s unclear what the exact relationship is.

So the search to understand and cure migraine continues with a very promising lead.

You should consult your doctor about headaches or visual disturbances.

——Important Message——-

If you get headaches and have brain fog – pay close attention: this will “youthify” your brain…

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.
Fremanezumab for the Preventive Treatment of Chronic Migraine. https://www.ncbi.nlm.nih.gov/pubmed/29171818

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