Is this bitter oil better than ibuprofen?

Is this bitter oil better than Ibuprofen?

[cmamad id=”13019″ align=”center” tabid=”display-desktop” mobid=”display-desktop” stg=””]
Don’t risk liver damage by using ibuprofen… instead, go for this oil from the grocery store that is 5 times as powerful…

——Important Message——-

“My wife needed more time to get hot and wet…here’s what I did”

I realized that she was just getting her motor running by the time I was finishing…

I wanted to please her and be a better lover.

I needed a way to get hard and keep my erections longer…long enough to give her what she wanted. And I knew that would give me a lot more pleasure too.

But I couldn’t last long enough.

I tried creams, lotions… this, that, and the other thing…

Finally what worked for me was these simple movements that let me last and last and last… She wants me more because I can spend enough time inside her to really get her motor running

This are the simple movements I’m doing now…

————–

Is this bitter oil better than ibuprofen?

Of all the things that have been invoked to explain the “French paradox,” this one actually has some merit.

The term “French paradox” was first coined in 1987. It’s about the fact that the French have very little cardiovascular disease despite eating a lot of fat.

Since then, biochemists, dietitians, and doctors have theorized many reasons for this alleged paradox – most notably involving resveratrol, or α-linolenic acid.

The French paradox really isn’t even paradoxical anyway, since it was shown in the early 1960s that fat has little to do with cardiovascular disease (Pauling, Prior).

The “French paradox” has become a persistent myth.

It is pulled out constantly to market ideas and to market foods.

One good thing did arise from this myth – it stimulated lots of research.

There have been hundreds of studies done that detail the chemical and pharmacological nature of French cuisine.

Scientists learned a few interesting things.

One that’s really worth mentioning is oleuropein.

[cmamad id=”13020″ align=”center” tabid=”display-desktop” mobid=”display-desktop” stg=””]
Oleuropein is a molecule found in olives, olive oil, and anything else olive.

It is a powerful inhibitor of COX-2, the enzyme which turns arachidonic acid into a powerful class of pro-inflammatory compounds: Prostaglandins.

Arachidonic acid exists in the cell membrane and can be released by any disturbance.

That could be anything from bacteria to physical trauma.

This is how the cell knows its under attack: The disrupted arachidonic acid dislodged from the cell membrane acts like a hormone inside the cell – an intracrine hormone.

The dislodged arachidonic acid is further modified by enzymes and detected in the nucleus.

Plants do something similar for defense, and prostaglandins probably had this function originally.

Reactive peroxide and cyclo-oxide groups are added to arachidonic acid to make prostaglandins, which are damaging to bacteria.

Cells have developed other ways to amplify this effect:

A cell can create inflammatory cytokines that release arachidonic acid from other cells’ membranes – a paracrine signal, a cell-to-cell event.

Treatments have been designed to inhibit this prostaglandin-based amplification scheme – the inflammation cascade.

Oleuropein has recently been found quite effective in doing this.

It doesn’t just work as well as the common treatments, it often works better.

This was shown in 2005 by Pennsylvania chemist and pharmacologist Gary Beauchamp:


He tested oleocanthal, the molecule in olive oil which causes that odd burning sensation in your throat.

Oleocanthal is formed from oleuropein by the action of heat, UV light, and enzymes.

Oleuropein converts to oleocanthal in the body. So, on a practical level, they are much the same thing.  

Beauchamp found that gram-for-gram, oleocanthal is more powerful at inhibiting the COX-2 enzyme than ibuprofen.


And not quite as powerful as indomethacin, but close.

Oleuropein and oleocanthal have far fewer side-effects, though.

Oleocanthal is one of the reasons that olive oil is generally considered to be the second best food oil, after coconut.

“Our findings raise the possibility that long-term consumption of oleocanthal may help to protect against some diseases by virtue of its ibuprofen-like COX-inhibiting activity.” ―Beauchamp

Though olive oil does contain some linoleic acid, it has the prostaglandin inhibitors to counter it.

And the fats in olive oil are mostly monounsaturated, an improvement over the polyunsaturated ones found in corn and canola oils.

Not only had oleuropein been shown to inhibit the COX-2 enzyme when isolated, it has been shown to do this in vivo, in rats.


Stimulated by Beauchamp’s study, these Italian scientists decided to test these effects directly on animals.

They injected the powerful seaweed allergen carrageenan directly into rats and measured the resulting inflammation.

All inflammatory markers were much lower in the oleuropein groups.

And most importantly, both TNF-α and interleukin-1β were lower. These are powerful cytokines made by white blood cells for signaling.


This effect was later confirmed by independent researchers (Scotece, 2012).

These cytokines work by disrupting the cell membrane and releasing arachidonic acid – the only precursor for inflammatory prostaglandins.

Most cytokines contain an enzyme called phospholipase A₂ that cleaves off arachidonic acid from the membrane.

This is where oleuropein comes into play.

It inhibits the transformation of arachidonic acid into prostaglandins. And it does this by inhibiting the COX-2 enzyme.

“Oleocanthal also inhibits interleukin-1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), and granulocyte-macrophage-colony-stimulating factor (GM-CSF) protein synthesis from lipopolysaccharide-stimulated macrophages.” ― Scotece

Scotece also stained for ICAM-1 (intercellular adhesion molecule 1), a characteristic protein created through the action of interleukin-1 beta on the target cell.

This is a reliable indicator of prostaglandin activity.

The creation of ICAM-1 is mediated by prostaglandins, and cannot be made without them.

Oleuropein inhibits this process with COX-2 in a binding event that makes prostaglandin formation impossible and ICAM-1 staining undetectable.


With the COX-2 enzyme knocked out by oleuropein, not one of these inflammatory cytokines can do anything – at all.

Oleuropein hijacks the inflammatory signal in transit from the white blood cell to the lung cell – from the cytokine to the prostaglandin.

“Thus, oleuropein is a novel, naturally occurring antioxidant compound, which may possibly be used to resolve problems of clinical relevance.” ―Impellizzeri

This is how aspirin, indomethacin, and ibuprofen do what they do.

But oleuropein does this even better than ibuprofen… without the liver damage.

Oleuropein has also been tested on the skin, highlighting the critical role inflammation has in hair loss.


This is not a totally new observation.

Prostaglandins and their inhibitors have been shown before to control the hair cycle.

Several patents have even been issued as a result.

Some prostaglandins (like J₂) powerfully disrupt the hair cycle.

Three groups of mice were used in this study: a control group, a minoxidil group (15,000 ppm), and an oleuropein group (2,000 ppm).

Most hair growth occurred in the oleuropein group.


So that’s just another indication that prostaglandins are involved in hair loss and growth.

In this study, oleuropein had caused a gene shift towards positive hair growth factors.

Vascular endothelial growth factor, insulin-like growth factor, and keratinocyte growth factor all more than doubled.

Another recent study found that…

males with hair loss had predictably higher levels of prostaglandin J₂ and D₂.

These are both downstream from COX-2, so they are both inhibited by oleuropein.

Apparently, this is what is causing the hair growth – the reduction in total prostaglandin concentration:


Or perhaps it’s substituting for prostaglandin F₂, the only prostaglandin which spikes before growth starts in the hair cycle.

This particular prostaglandin could actually be a stimulus, but further investigation is needed.

Oleuropein has also been found to inhibit 5-lipoxygenase, another eicosanoid enzyme.

Oleuropein has been shown to inhibit the production of leukotriene B₄ (de la Puerta, 1999).

Not all pathways have been fully explored with oleuropein, yet.

But it’s indisputable that oleuropein works in a positive manner.

And it undoubtedly inhibits COX-2.

It’s hard to imagine that it’s working on any other level besides the eicosanoid-prostaglandin system.

The molecular structure is also suggestive of eicosanoid-prostaglandin involvement.

“In acute toxicity studies for oleuropein, no lethality or adverse effects were observed in mice even when it was administered at doses as high as 1,000 mg/kg. Therefore, an LD50 (median lethal dose) value could not be determined.” ―Tong

Unfortunately, olives, olive oil, and olive leaves have only mildly-effective amounts of oleuropein.

It’s true that the olive tree has higher concentrations of it than anything else, but not in the amounts that promote hair growth.

Moreover, the concentrations of oleuropein vary widely from tree to tree and from olive oil to olive oil.


Even at the highest concentration found, oleuropein in olive oil never exceeds the concentration proven to cause hair growth.

The highest concentration found in olive oil was 11,226 parts per billion.

The rats in the study were given 180 times this amount, and you’d have difficulty finding an olive oil for sale with an oleuropein concentration this high.

The high-phenolic oils are probably too bitter to sell to most Westerners and aren’t normally part of the export stream anyway.  

Fortunately, the pure compound is extracted, and you can get this.

The cytokine TGF-β₁ (transforming growth factor beta-1) releases arachidonic acid from the cell membrane, creating prostaglandins within (Han, 2004).

This is important, as it’s recently been shown that TGF-β₁ is released by aldosterone (Han, 2009).

And this is a direct link from aldosterone, cortisol, and stress to the inflammatory prostaglandin cascade.

Cortisol/Aldosterone TGF-β₁ ⟶ Prostaglandin J₂ ⟶ Hair Loss

Prostaglandins operate on a more fundamental level, downstream of steroid and protein hormones.

Anything that stops the process at that point should be effective.

—-Important Message—-

Two steps to ending inflammation and fixing diabetes.

Yes, diabetics have a problem – because of inflammation inside their bodies…

The diabetic man can NOT easily burn sugar.

His cells are STUCK burning fats. So the sugar piles up in the blood.

The trick to FIXING diabetes lays in:

  1. Stopping the inflammation
  2. Stopping the cells from burning fat, so they are FORCED to burn sugar

I found that niacinamide, thiamine, biotin and many other nutritional supplements can actually fix inflammation AND activate sugar-burning again.

I tested these and put them together using bags of VERY cheap supplements you can order from Amazon…

and these can often REVERSE diabetes symptoms.

———

 

 


Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.
Beauchamp, Gary K., et al. "Phytochemistry: ibuprofen-like activity in extra-virgin olive oil." Nature 437.7055 (2005) 
http://www.direct-ms.org/pdf/NutritionOther/Olive%20Oil%20anti-inflammatory.pdf 

Impellizzeri, Daniela, et al. "The effects of oleuropein aglycone, an olive oil compound, in a mouse model of carrageenan-induced pleurisy." Clinical Nutrition 30.4 (2011) 
http://www.academia.edu/download/44734388/The_effects_of_oleuropein_aglycone_an_ol 20160414-17577-pwoilq.pdf 

Perri, Enzo, Andrea Raffaelli, and Giovanni Sindona. "Quantitation of oleuropein in virgin olive oil by ionspray mass spectrometry− selected reaction monitoring." Journal of agricultural and food chemistry 47.10 (1999): 4156-4160. 
http://sci-hub.cc/http://pubs.acs.org/doi/abs/10.1021/jf981161d 

Tong, Tao, Nahyun Kim, and Taesun Park. "Topical application of oleuropein induces anagen hair growth in telogen mouse skin." PloS one 10.6 (2015): e0129578. 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462586/ 

https://www.naturalremedies.org/oleuropein/ 

http://www.beinkandescent.com/articles/980/power+of+olive-oil 

https://www.organicfacts.net/health-benefits/oils/coconut-oil-for-hair.html 

https://www.healthline.com/nutrition/best-vitamins-hair-growth 

1.What are the benefits of coconut oil for hair? 
Coconut oil is rich in antimicrobial and antibacterial properties ,as well as has the right proportion of fatty acids to keep the hair healthy.Packed with the richness of carbohydrates, vitamins and minerals that are good for the human body,coconut oil is a blessing when it comes to the upkeep of hair.The use of sage in coconut oil or gooseberry leaves has been an age old secret in Ayurveda in combating hair fall and in rebuilding the roots of the hair follicles. The regular use of coconut oil helps in reducing the protein loss in damaged hair. Coconut oil is also very rich in lauric acid which helps to keep the hair roots healthy and shiny.Coconut oil is also termed as a cooling oil and a great conditioner. Coconut oil is also good for controlling excess dandruff. Regular application of coconut oil mixed with a little castor oil can do wonders for the hair follicles. In individuals who are suffering from dry hair problems, coconut oil is a boon. Not only is the coconut oil a great toning agent but it also helps to soften and nourish the dry hair to make it more manageable and healthy. Coconut oil is also considered a wonderful oil for hair types with split ends as it helps in nourishing the hair and protects it from loss of moisture. For individuals who have excessive scalp sweating, regular massage of coconut oil into the scalp does wonders for the skin. 

2.  What vitamins are good for hair growth? 
According to random research studies the proper use of vitamins can do wonders to the overall quality and health of the hair. Great looking shiny hair is a sign of the care and love that goes into keeping them well conditioned. The best vitamins  for hair growth are Vitamin A, Vitamin B, Vitamin C,Vitamin D, Iron, Zinc and proteins. Most of these Vitamins and other minerals can be found in vegetables and fruits ,but then in many cases taking a supplement can also help avail the needed ingredients for your hair growth.Vitamin A is very important in the production of sebum which is produced by the skin glands for the upkeep of the hair. Some of the foods which has a abundance of Vitamin A are sweet potatoes, carrots, pumpkin, spinach and kale.Milk,eggs,yogurt and cod liver oil are also believed to be great resources.Vitamins like biotin is very important in the upkeep of the hair. Some of the foods which can supplement biotin for the hair upkeep are Whole grains, almonds, seafood and dark leafy vegetables. Vitamin C is a great antioxidant and can help keep free radicals at bay and protect the hair from excessive damage. Vitamin C also plays a major role in the absorption of Iron which is necessary for hair growth. Some sources of Vitamin C are guavas, citrus fruits, Peppers and strawberries. Vitamin D is also important when it comes to the growth of new hair on the scalp. Naturally available in sunlight, some great food sources are cod liver oil, fatty fish and some specific forms of mushrooms. Iron helps boost the flow of oxygen to the cells ,the deficiency of which can cause hair loss. Foods that are considered rich in iron are red meat, spinach and lentils which plays a significant role in the upkeep of great hair health.The best way to get all these nutrients in the hair is by eating a variety filled balanced diet which contains a equal helping of vegetables and fruits, dairy product and meat along with unprocessed whole grains that keep the body hale and healthy.  

Be the first to comment

Leave a Reply

Your email address will not be published.