Is it really doing anyone any good?
This popular prostate “remedy” promotes a fatty liver
Hey, Matt Cook here, and non-alcoholic fatty liver disease is liver dysfunction caused by the buildup of fat inside the liver.
It’s usually associated with insulin resistance and central obesity – the buildup of fat around the middle part of the body.
It’s an increasingly common problem – and one with numerous causes…
A few years ago, research emerged showing that this increasing liver fat can be caused by inhibition of 5α-Reductase.
This is an enzyme which converts hormones – including converting testosterone to the alpha male hormone DHT.
As you’re probably aware, DHT has been blamed for prostate problems and baldness… incorrectly so.
But DHT-lowering treatments have become widely prescribed for men.
These treatments inhibit the 5α-Reductase enzyme – lowering DHT.
And research shows that they can cause an increase in liver fat.
5α-Reductase inhibitors may be a major cause of non-alcoholic fatty liver disease.
But by the same token, perhaps increasing 5α-Reductase – or DHT could help reverse non-alcoholic fatty liver disease.
The human research was carried out at the University of Oxford in the UK. The paper was published in The Journal of Clinical Endocrinology & Metabolism.
The researchers were looking at the effect of treatments which interfere with two versions of 5α-Reductase -a hormone converting enzyme.
“5α-Reductase 1 and 2 inactivate cortisol to 5α-dihydrocortisol in addition to their role in the generation of DHT.”
The treatments in question are dutasteride and finasteride – both used for prostate problems – particularly benign prostate hyperplasia.
“Dutasteride (5α-Reductase 1 and 2) and finasteride (5α-Reductase 2 inhibitor) are commonly prescribed, but their potential metabolic effects have only recently been identified.”
Many years after their introduction into widespread use in men, researchers decided to investigate the metabolic effects of these treatments.
“Our objective was to provide a detailed assessment of the metabolic effects of 5α-Reductase inhibition and in particular the impact on hepatic lipid metabolism.”
The researchers carried out their experiments in 12 healthy men.
The researchers carried out extensive metabolic work-ups of these men, including blood tests and high-tech liver scans.
Then the men were given one of the two medications.
They took the treatments for a few weeks before being re-tested.
“We conducted a randomized study in 12 healthy male volunteers with detailed metabolic phenotyping performed before and after a 3-week treatment with finasteride (5 mg od) or dutasteride (0.5 mg od).”
The first finding was that one of these treatments increased insulin resistance.
“Dutasteride, not finasteride, increased hepatic insulin resistance.”
Dutasteride also led to a rapid increase in fat buildup in the liver.
The treatment was causing liver cells to produce fat at an accelerated rate – something which could well lead to non-alcoholic fatty liver disease.
“Intrahepatic lipid increased after dutasteride treatment and was associated with increased rates of de novo lipogenesis.”
A second effect was that dutasteride seemed to cause fat to hang around in the liver longer.
“Adipose tissue lipid mobilization was decreased by dutasteride.”
The research shows that some of these prostate medications can have numerous detrimental effects on energetic metabolism.
Dutasteride can cause insulin resistance and elevate the amount of fat in the liver.
“Dual-5α-Reductase inhibition with dutasteride is associated with increased intrahepatic lipid accumulation.”
These “treatments” could well be playing into the myriad of metabolic problems men are suffering with these days…
Non-alcoholic fatty liver disease is a logical conclusion of the effects which were seen in this experiment.
What’s even worse is that the problems these treatments are supposed to solve are not caused by DHT at all.
These prostate problems are caused by other things like bacterial infection, high serotonin, high estrogen and high prolactin.
Men are being given a cocktail of pharmaceuticals which completely messes up their hormones without dealing with the real root of their problems.
And it seems that some of these treatments also have major detrimental effects on metabolic and liver health too.
You should always consult your healthcare practitioner for guidance on medical diagnosis and treatment.
—-Important Message—-
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Most men don’t know that getting good erections is tied to having a clean liver.
So men with fatty livers are often suffering from erections problems, but don’t know why.
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