This could be the key to losing fat, stopping inflammation, and even living longer
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Chemical blocker RU486
Cortisol is an essential hormone.
One of the essential things it does is break down muscle and fat to create fuel to keep us going when we haven’t eaten in a while.
But chronically elevated cortisol is a big problem.
Stress increases cortisol…
And when cortisol is elevated for long periods of time, it causes all sorts of health problems.
In the last 10 years there has been a lot of research showing that elevated levels of cortisol may play a role in metabolic problems.
What’s more, cortisol also seems to trigger the cardiovascular problems associated with obesity, diabetes and the metabolic syndrome.
Recent experiments support this idea – showing that blocking cortisol receptors can mitigate many of the cardio-metabolic problems the majority of people suffer with these days.
The science underlines what I’ve been saying for years:
It’s critical that you keep your cortisol levels under control.
The animal experiments were performed at Nagoya University in Japan. The paper was published in Hypertension Research.
Cortisol is one of a class of hormones known as glucocorticoids.
They have a number of essential and a number of detrimental effects on the body.
“Glucocorticoids are stress hormones that modulate metabolic, inflammatory and cardiovascular processes.”
Animal hormones are slightly different – they have an alternative glucocorticoid to cortisol known as corticosterone.
Researchers are studying the effects of corticosterone on metabolic problems in animals to learn more about human disease.
“We recently mutated obese rats as a new animal model of metabolic syndrome.”
Glucocorticoids like cortisol and corticosterone exert many of their effects by activating the glucocorticoid receptor.
So the researchers are doing experiments blocking this receptor to learn more about these hormones.
“We have now investigated the effects of glucocorticoid receptor blockade on cardiac and fat tissue, as well as on glucose metabolism.”
Chemists have come up with a very potent glucocorticoid receptor blocker called RU486.
It is helping us to learn a lot about cortisol.
“The obese rats were treated with the glucocorticoid receptor blocker RU486 for 4 weeks beginning at 9 weeks of age.”
The experiments showed that obese rats treated with this cortisol blocker had healthier hearts.
Blocking the cortisol receptor reduced fibrosis (damaging scar tissue) in the heart and minimized alterations in diastolic function.
The research shows that controlling cortisol may minimize cardiovascular disease in people with metabolic problems.
“Treatment of obese rats with RU486 attenuated left ventricular fibrosis and diastolic dysfunction.”
The researchers also found that the cortisol blocker reduced inflammation in the heart.
It decreased oxidative stress – rogue electrons which damage cell membranes and DNA.
“RU486 treatment also attenuated cardiac oxidative stress and inflammation, without affecting hypertension or hypertrophy.”
The cortisol blocker also decreased an enzyme involved in the creation of cortisol and corticosterone in the heart.
In other words, the animals would have had lower levels of these stress hormones.
“Administration of RU486 inhibited the upregulation of 11β-HSD1 expression at the mRNA and protein levels in the heart.”
As other studies have shown – acting against glucocorticoids reduces fatness.
Animals given cortisol blockers carried less body fat and this fat was producing less inflammation.
It seems that the inflammatory proteins which are largely produced in fat cells…
…can be a major trigger for many of the metabolic problems associated with obesity.
“RU486 attenuated adiposity and adipose tissue inflammation.”
The cortisol blocking treatment also led to significant improvements in insulin and blood sugar regulation.
“RU486 ameliorated fasting hyperinsulinemia as well as insulin resistance and glucose intolerance.”
The results are in line with a lot of other research done over the past decade showing that glucocorticoids like cortisol play a major role in metabolic and cardiovascular disease.
“Our results thus implicate the glucocorticoid axis in the pathophysiology of metabolic syndrome, and they suggest that glucocorticoid receptor blockade has therapeutic potential for the treatment of this condition.”
We may see cortisol blocking treatments on the market at some point in the future…
Until then we need to take steps to keep our cortisol levels under control naturally.
You should always consult your healthcare practitioner for guidance on medical diagnosis and treatment.
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