Yet doctors will say the opposite…
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This is a big red flag for prostate cancer
One in 1000 men will be diagnosed with prostate cancer every year.
But very few of these diagnoses are serious.
Prostate cancer is an overdiagnosed disease.
Another problem is the use of prostate-specific antigen (PSA) to assess prostate cancer risk.
PSA is simply a marker of prostate inflammation.
Finally, we have a great degree of confusion over the relationship between hormones and serious prostate cancer.
The major hormones which increase the risk of prostate cancer are estrogen and prolactin.
But many men still believe that hormones like testosterone and DHT increase the risk of prostate cancer.
Let’s take a look at a study which investigated the relationship between pretreatment testosterone levels and the severity of prostate diagnosis.
The human research was carried out at Memorial Sloan-Kettering Cancer Center in New York. The paper was published in the Journal of Urology.
In recent decades, the male hormone DHT has been charged with causing prostate cancer.
DHT is made from testosterone – and so testosterone has been implicated too.
But these are very superficial claims – and many in the science research community are becoming skeptical.
“Substantial controversy exists in the literature regarding the association between pretreatment testosterone and disease outcome in patients with prostate cancer.”
This paper the relationship between prostate cancer stage and testosterone levels in men before they had surgery for prostate cancer.
“We retrospectively reviewed the records of consecutive patients with clinically localized prostate cancer treated with radical prostatectomy between January 1990 and June 2003.”
The researchers analyzed information from over 300 men who had testosterone tests before undergoing surgery to remove their prostates.
The researchers looked at the physical signs of cancer as well as prostate-specific antigen (PSA) – a protein which indicates increased inflammation in the prostate.
“Biochemical progression was defined by postoperative prostate specific antigen (PSA) greater than 0.4 ng/ml.”
In three quarters of the men, cancer was confirmed during the prostate removal surgery.
“In 245 patients (75%) disease was organ confined.”
The research showed that lower testosterone was associated with more aggressive prostate cancer.
Biopsy grade and prostate cancer stage were both worse in men with lower testosterone.
“Lower testosterone correlated with adverse pathological stage on multivariate analysis, as did clinical stage, biopsy grade and PSA.”
The researchers found no clear relationship between testosterone in PSA – but cancer stage and biopsy grade (not PSA) are the gold standard for cancer.
“However, we found no relationship between testosterone and biochemical progression (PSA) after adjusting for covariates.”
Some previous studies indicate that DHT can actually lower PSA – but this study found no relationship between PSA and testosterone.
“Furthermore, we found no evidence of an interaction between PSA and testosterone.”
The important finding is that lower testosterone is associated with more aggressive prostate cancer.
This is probably due to a number of factors.
Hormones that precede testosterone are anti-inflammatory and anti-cancer.
Testosterone and its derivative, DHT, are also anti-inflammatory and should be expected to decrease the risk of cancer.
As I have written about in the newsletters there are numerous lines of research showing that DHT testosterone do help with prostate cancer – even if there are endless headlines claiming the opposite.
“Low preoperative total testosterone was associated with advanced pathological stage but not with biochemical progression (PSA).”
The authors called for further research into the topic.
“Future studies are warranted with data on more patients who have progressed.”
There is already a lot of research showing that the common ideas about prostate cancer and hormones are incorrect.
But there is a lot of money and there are many reputations on the line – so don’t expect the headlines to change any time soon.
You should always consult your healthcare practitioner for guidance on medical diagnosis and treatment.
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