I think this might be going in the right direction for a change
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They’re changing how they’re treating the big C
The standard treatment for most types of cancer is radiation, chemotherapy, and surgery.
But there are problems with this approach…
In many cases, patients have recurrences of cancer…
…and because it becomes resistant to treatment, it’s harder to get rid of in subsequent treatments.
Most cancer treatments are based on using the maximum tolerated dose of a drug to kill as many cancer cells as possible. While this approach has led to patients achieving good responses to therapy, most patients develop drug resistance and disease recurrence.
In addition to cancer coming back, the initial treatment for cancer is also extremely strenuous, painful, and difficult for those who are going through it.
The only reason that people subject themselves to this kind of treatment is because it’s marketed as being the only and best option for cancer.
That’s why researchers are starting to test alternative approaches to cancer treatments.
Right now, there are tests for an approach called adaptive therapy that is less aggressive…
…and is more about managing the cancer and potential cancer growth then it is about getting every single cancer cell out of the body.
The emerging concept of adaptive therapy is based on ecological principles that predict that maintaining a population of cancer cells that is sensitive to therapies will keep the development of resistance in check through competition.
This is a fairly new idea, but the results so far have been encouraging.
Clinical trials have been done with both melanoma and prostate cancer patients.
Promising results were observed from a recent early-stage clinical trial of prostate cancer patients treated with adaptive therapy, and additional larger clinical studies of adaptive therapy are underway in prostate cancer and melanoma.
The goal of adaptive therapy is to keep the tumor in check rather than eradicate every single cell of the tumor.
It’s a very different approach than what has been used in most cancer treatments so far.
Adaptive therapy is an evolution-based treatment approach that aims to maintain tumor volume by employing minimum effective drug doses or timed drug holidays.
This type of therapy has been shown to have greater long term survival than high dose therapies.
The goal of adaptive therapy is to enforce a stable tumor burden by permitting a significant population of chemosensitive cells to survive so that they, in turn, suppress proliferation of the less fit but chemoresistant subpopulations. Computer simulations show that this strategy can result in prolonged survival that is substantially greater than that of high dose density or metronomic therapies.
Even though adaptive therapy is promising, it’s not without its challenges.
It’s hard to optimize the treatment timing and scientists don’t yet have a good grasp of how to tell who this approach will work for the best.
Several challenges exist in designing adaptive therapies. First, optimizing the timing of treatment withdrawal and re-challenge for each patient is difficult to implement in clinical practice. Second, it is critical to identify predictive factors for selecting patients who will likely benefit the most from this adaptive therapy.
Overall, I’m encouraged by this approach.
It’s better to avoid getting cancer in the first place whenever possible…
…but if you do get cancer, it’s a good thing that more options for treatments are being developed all the time.
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