Unspoken risk of having surgery

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Unspoken risk of having surgery

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Any sort of trauma can cause inflammation.

The older we get, the more likely we are to have elevated inflammation and a decreased ability to clean that inflammation up quickly.

This problem is shown in experiments where older mice undergo minor surgical procedures.

The procedures led to increased inflammation in the brain, even though the researchers were operating on the abdominal area.

The research highlights the importance of reducing inflammation during surgery, even minor surgery, especially in older folks.

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The animal experiments were performed at the University of Illinois. This paper was published in Experimental Gerontology.

The researchers were looking into the roots of something called postoperative cognitive dysfunction. This is a technical term given to mental problems experienced after surgery.

Everyone experiences grogginess after surgery, but for older folks, a mental deficiency can persist long after the effects of anesthesia and painkillers have worn off.

“Following surgery, elderly patients often suffer from postoperative cognitive dysfunction (POCD), which can persist long after physical recovery.”

One of the issues is damage caused by tissue during surgery.

Damaged tissue sends out signals and inflammatory mediators.

Those inflammatory mediators can travel right through the body and tell the rest of the body to initiate inflammation.

Harm to any part of the body can inflame the brain.

“It is known that surgery-induced tissue damage activates the peripheral innate immune system resulting in the release of inflammatory mediators.”

This increased systemic inflammation is one reason why even minor surgeries can cause cognitive problems in older folks.

“Compared to adults, aged animals demonstrate increased neuroinflammation and microglial priming that leads to an exaggerated proinflammatory cytokine response following activation of the peripheral immune system.”

The researchers decided to test this idea in their experiments.

“Therefore, we sought to determine if the immune response to surgical trauma results in increased neuroinflammation and cognitive impairment in aged mice.”

They performed minor abdominal surgery in mice and then tested the levels of inflammatory proteins in the brains of those mice 24 hours later to see if they were elevated.

The mice were also put through a memory test before and after the procedure.

“Adult and aged mice underwent minor abdominal surgery, and 24 hours later hippocampal cytokines were measured, and working memory was assessed in a reversal learning version of the Morris water maze.”

The researchers found significantly elevated levels of inflammatory proteins in the brains of older mice after minor abdominal surgery.

“While adult mice showed no signs of neuroinflammation following surgery, aged mice had significantly increased levels of IL-1beta mRNA in the hippocampus.”

Even this minor abdominal surgery was enough to cause some changes in memory and mental function.

“Minor surgery did not result in severe cognitive impairment, although aged mice that underwent surgery did tend to perseverate in the old target during reversal testing, suggesting reduced cognitive flexibility.”

The researchers confirmed that surgery anywhere in the body could trigger brain inflammation, which is far more likely in older animals.

“Overall, these results suggest that minor surgery leads to an exaggerated neuroinflammatory response in aged mice but does not result in significantly impaired performance in the Morris water maze.”

There are quite a number of things that can help to restrain systemic inflammation, reducing the problem exhibited by these experiments.

Optimizing vitamin D levels helps to restrain systemic inflammation. In addition, it has been shown to limit the production of the inflammatory protein identified in this study (IL-1beta).

L-theanine, a compound found in tea, also has proven neurological benefits, reducing brain inflammation.

If you don’t have access to a supplement of L-theanine, then drinking one or two cups of tea per day after surgery might help.

The minerals magnesium and zinc reduce neuroinflammation.

Berries and dark chocolate also help to protect the brain against systemic inflammatory signals.

You should always consult your healthcare practitioner for medical diagnosis and treatment guidance.

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Matt Cook is editor-in-chief of Daily Medical Discoveries. Matt has been a full time health researcher for 26 years. ABC News interviewed Matt on sexual health issues not long ago. Matt is widely quoted on over 1,000,000 websites. He has over 300,000 daily newsletter readers. Daily Medical Discoveries finds hidden, buried or ignored medical studies through the lens of 100 years of proven science. Matt heads up the editorial team of scientists and health researchers. Each discovery is based upon primary studies from peer reviewed science sources following the Daily Medical Discoveries 7 Step Process to ensure accuracy.
https://pubmed.ncbi.nlm.nih.gov/18602982/